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Developing Novel Chemotherapeutics: A Structure-Activity Study of Anandamide Analogs and their Cytotoxic Profiles
(East Carolina University, 2020-01-06)
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzyme responsible for both the metabolism of arachidonic acid (AA) to prostaglandins and arachidonoyl ethanolamine (AEA) to ...
Harriet Beecher Stowe and the Debate Between Frederick Douglass and Martin Delany
(East Carolina University, 2020-01-06)
Martin Delany had different ideas about Uncle Tom's Cabin than did Frederick Douglass. Delany wrote his concerns in a series of letters that were published in Douglass' newspaper. Delany stated that Harriet Beecher Stowe ...
CHARACTERIZATION AND DEVELOPMENT OF FRACTURE PATTERNS IN DOMED SEDIMENTARY STRATA, PULPIT ARCH, HENRY MOUNTAINS, UTAH
(East Carolina University, 2020-01-10)
Fractures in sedimentary rock can be an important factor in influencing fluid migration in the subsurface. In high-porosity sandstones in the upper crust, deformation such as folding typically results in the production of ...
Social Factors Key to Landscape-Scale Coastal Restoration: Lessons Learned from Three U.S. Case Studies
(2020-01-23)
In the United States, extensive investments have been made to restore the ecological function and services of coastal marine habitats. Despite a growing body of science supporting coastal restoration, few studies have ...
Inherent Fibrin Fiber Tension Propels Mechanisms of Network Clearance During Fibrinolysis
(2020-02-25)
Proper wound healing necessitates both coagulation (the formation of a blood clot) and fibrinolysis (the dissolution of a blood clot). A thrombus resistant to clot dissolution can obstruct blood flow, leading to vascular ...
SUPPORTING TEACHER-WRITERS ENGAGEMENT WITH TROUBLESOME KNOWLEDGE: EVIDENCE OF TRANSFER IN WRITING ACROSS THE CURRICULUM PROFESSIONAL DEVELOPMENT
(East Carolina University, 2020-06-22)
Writing Across the Curriculum has typically been discussed in terms of curricular or pedagogical transformation. While it helped to transform teaching from lecture-centered classrooms into more student-centered pedagogies, ...
IMPACT OF INTRINSIC AEROBIC EXERCISE CAPACITY ON CARDIOVASCULAR OUTCOMES FOLLOWING VARIOUS FORMS OF CARDIOVASCULAR STRESS
(East Carolina University, 2020-06-22)
Cardiovascular diseases (CVD) remain the major leading cause of death in the western world. Therefore, several approaches to achieve cardioprotection against any cardiovascular insult have been explored and to date, the ...
MANIPULATION OF FLOODING AND NUTRIENTS INFLUENCES PLANT-MICROBE INTERACTIONS AND WETLAND FUNCTION
(East Carolina University, 2020-06-22)
The largest global stocks of organic carbon are in soils, where plants fix atmospheric carbon dioxide into biomass at higher rates than soil organic carbon is lost through decomposition and microbial respiration. Specifically, ...
Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio)
(East Carolina University, 2020-06-22)
It is well known that progestins initiate important reproductive processes such as oocyte maturation and ovulation in vertebrates. Progestins exert functions through binding to progestin receptors. At least three families ...
IMPACTS OF A BRIEF, PILOT SELF-COMPASSION PROGRAM FOR WOMEN WITH OVERWEIGHT/OBESITY AND INTERNALIZED WEIGHT BIAS
(East Carolina University, 8/5/2020)
Internalization of weight bias occurs when one believes negative weight-related stereotypes to be true of themselves, such as believing that one is deserving of disrespect, or unworthy of partnership due to weight status ...