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    Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

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    ijms-16-11055.PMC4463690.pdf (996.1Kb)

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    Author
    Justus, Calvin R.; Sanderlin, Edward J.; Yang, Li V.
    Abstract
    Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemoprevention.
    URI
    http://hdl.handle.net/10342/5545
    Subject
     tumor microenvironment; cancer cell metabolism; hypoxia; acidosis; cancer therapy 
    Date
    2015-05
    Citation:
    APA:
    Justus, Calvin R., & Sanderlin, Edward J., & Yang, Li V.. (May 2015). Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment. International Journal of Molecular Sciences, (16:5), p.11055-11086. Retrieved from http://hdl.handle.net/10342/5545

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    MLA:
    Justus, Calvin R., and Sanderlin, Edward J., and Yang, Li V.. "Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment". International Journal of Molecular Sciences. 16:5. (11055-11086.), May 2015. February 26, 2021. http://hdl.handle.net/10342/5545.
    Chicago:
    Justus, Calvin R. and Sanderlin, Edward J. and Yang, Li V., "Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment," International Journal of Molecular Sciences 16, no. 5 (May 2015), http://hdl.handle.net/10342/5545 (accessed February 26, 2021).
    AMA:
    Justus, Calvin R., Sanderlin, Edward J., Yang, Li V.. Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment. International Journal of Molecular Sciences. May 2015; 16(5) 11055-11086. http://hdl.handle.net/10342/5545. Accessed February 26, 2021.
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