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    Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes

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    oncotarget-03-1522.PMC3681491.pdf (628.5Kb)

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    Author
    Berman, Albert E.; Leontieva, Olga V.; Natarajan, Venkatesh; McCubrey, James A.; Demidenko, Zoya N.; Nikiforov, Mikhail A.
    Abstract
    It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm is being replaced by the “hyperfunction theory”, which postulates that aging is caused by activation of signal transduction pathways such as TOR (Target of Rapamycin). These pathways consist of different enzymes, mostly kinases, but also phosphatases, deacetylases, GTPases, and some other molecules that cause overactivation of normal cellular functions. Overactivation of these sensory signal transduction pathways can cause cellular senescence, age-related diseases, including cancer, and shorten life span. Here we review some of the numerous very recent publications on the role of signal transduction molecules in aging and age-related diseases. As was emphasized by the author of the “hyperfunction model”, many (or actually all) of them also play roles in cancer. So these “participants” in pro-aging signaling pathways are actually very well acquainted to cancer researchers. A cancer-related journal such as Oncotarget is the perfect place for publication of such experimental studies, reviews and perspectives, as it can bridge the gap between cancer and aging researchers.
    URI
    http://hdl.handle.net/10342/5556
    Subject
     senescence; quasi-programmed aging; diseases; cancer 
    Date
    2012-12
    Citation:
    APA:
    Berman, Albert E., & Leontieva, Olga V., & Natarajan, Venkatesh, & McCubrey, James A., & Demidenko, Zoya N., & Nikiforov, Mikhail A.. (December 2012). Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget, 3(12), 1522- 1532. Retrieved from http://hdl.handle.net/10342/5556

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Berman, Albert E., and Leontieva, Olga V., and Natarajan, Venkatesh, and McCubrey, James A., and Demidenko, Zoya N., and Nikiforov, Mikhail A.. "Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes". Oncotarget. 3:12. (1522-1532), December 2012. October 03, 2023. http://hdl.handle.net/10342/5556.
    Chicago:
    Berman, Albert E. and Leontieva, Olga V. and Natarajan, Venkatesh and McCubrey, James A. and Demidenko, Zoya N. and Nikiforov, Mikhail A., "Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes," Oncotarget 3, no. 12 (December 2012), http://hdl.handle.net/10342/5556 (accessed October 03, 2023).
    AMA:
    Berman, Albert E., Leontieva, Olga V., Natarajan, Venkatesh, McCubrey, James A., Demidenko, Zoya N., Nikiforov, Mikhail A.. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget. December 2012; 3(12): 1522-1532. http://hdl.handle.net/10342/5556. Accessed October 03, 2023.
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