Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

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Author
Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Kempf, C. Ruth; Long, Jacquelyn M.; Laidler, Piotr; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Stivala, Franca; Mazzarino, Maria C.; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Nicoletti, Ferdinando; Libra, Massimo; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Bäsecke, Jörg; Cocco, Lucio; Evangelisti, Camilla; Martelli, Alberto M.; Montalto, Giuseppe; Cervello, Melchiorre; McCubrey, James A.
Abstract
Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.
URI
http://hdl.handle.net/10342/5665
Subject
 Raf; MEK; PI3K; mTOR; cancer; kinases; protein phosphorylation; signal transduction; apoptosis 
Date
2011-03
Citation:
APA:
Steelman, Linda S., & Chappell, William H., & Abrams, Stephen L., & Kempf, C. Ruth, & Long, Jacquelyn M., & Laidler, Piotr, & Mijatovic, Sanja, & Maksimovic-Ivanic, Danijela, & Stivala, Franca, & Mazzarino, Maria C., & Donia, Marco, & Fagone, Paolo, & Malaponte, Graziella, & Nicoletti, Ferdinando, & Libra, Massimo, & Milella, Michele, & Tafuri, Agostino, & Bonati, Antonio, & Bäsecke, Jörg, & Cocco, Lucio, & Evangelisti, Camilla, & Martelli, Alberto M., & Montalto, Giuseppe, & Cervello, Melchiorre, & McCubrey, James A.. (March 2011). Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY), 3(3), 192- 222. Retrieved from http://hdl.handle.net/10342/5665

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MLA:
Steelman, Linda S., and Chappell, William H., and Abrams, Stephen L., and Kempf, C. Ruth, and Long, Jacquelyn M., and Laidler, Piotr, and Mijatovic, Sanja, and Maksimovic-Ivanic, Danijela, and Stivala, Franca, and Mazzarino, Maria C., and Donia, Marco, and Fagone, Paolo, and Malaponte, Graziella, and Nicoletti, Ferdinando, and Libra, Massimo, and Milella, Michele, and Tafuri, Agostino, and Bonati, Antonio, and Bäsecke, Jörg, and Cocco, Lucio, and Evangelisti, Camilla, and Martelli, Alberto M., and Montalto, Giuseppe, and Cervello, Melchiorre, and McCubrey, James A.. "Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging". Aging (Albany NY). 3:3. (192-222), March 2011. September 27, 2023. http://hdl.handle.net/10342/5665.
Chicago:
Steelman, Linda S. and Chappell, William H. and Abrams, Stephen L. and Kempf, C. Ruth and Long, Jacquelyn M. and Laidler, Piotr and Mijatovic, Sanja and Maksimovic-Ivanic, Danijela and Stivala, Franca and Mazzarino, Maria C. and Donia, Marco and Fagone, Paolo and Malaponte, Graziella and Nicoletti, Ferdinando and Libra, Massimo and Milella, Michele and Tafuri, Agostino and Bonati, Antonio and Bäsecke, Jörg and Cocco, Lucio and Evangelisti, Camilla and Martelli, Alberto M. and Montalto, Giuseppe and Cervello, Melchiorre and McCubrey, James A., "Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging," Aging (Albany NY) 3, no. 3 (March 2011), http://hdl.handle.net/10342/5665 (accessed September 27, 2023).
AMA:
Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Kempf, C. Ruth, Long, Jacquelyn M., Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C., Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M., Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A.. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY). March 2011; 3(3): 192-222. http://hdl.handle.net/10342/5665. Accessed September 27, 2023.
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