Advances in Targeting Signal Transduction Pathways

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Author
McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Sun, Lin; Davis, Nicole Marie; Abrams, Stephen L.; Franklin, Richard A.; Cocco, Lucio; Evangelisti, Camilla; Chiarini, Francesca; Martelli, Alberto M.; Libra, Massimo; Candido, Saverio; Ligresti, Giovanni; Malaponte, Graziella; Mazzarino, Maria C.; Fagone, Paolo; Donia, Marco; Nicoletti, Ferdinando; Polesel, Jerry; Talamini, Renato; Bäsecke, Jörg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Milella, Michele; Tafuri, Agostino; Dulińska-Litewka, Joanna; Laidler, Piotr; D'Assoro, Antonino B.; Drobot, Lyudmyla B.; Umezawa, Kazuo; Montalto, Giuseppe; Cervello, Melchiorre; Demidenko, Zoya N.
Abstract
Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic mechanisms responsible for the development of resistance after targeted therapy are being discovered which may allow the creation of alternative therapies to overcome resistance. This review will discuss some of the highlights over the past few years on the roles of key signaling pathways in various diseases, the targeting of signal transduction pathways and the genetic mechanisms governing sensitivity and resistance to targeted therapies.
URI
http://hdl.handle.net/10342/5672
Subject
 Targeted Therapy; Therapy Resistance; Cancer Stem Cells; Raf; Akt; PI3K; mTOR; AMPK; Metformin 
Date
2012-12
Citation:
APA:
McCubrey, James A., & Steelman, Linda S., & Chappell, William H., & Sun, Lin, & Davis, Nicole Marie, & Abrams, Stephen L., & Franklin, Richard A., & Cocco, Lucio, & Evangelisti, Camilla, & Chiarini, Francesca, & Martelli, Alberto M., & Libra, Massimo, & Candido, Saverio, & Ligresti, Giovanni, & Malaponte, Graziella, & Mazzarino, Maria C., & Fagone, Paolo, & Donia, Marco, & Nicoletti, Ferdinando, & Polesel, Jerry, & Talamini, Renato, & Bäsecke, Jörg, & Mijatovic, Sanja, & Maksimovic-Ivanic, Danijela, & Milella, Michele, & Tafuri, Agostino, & Dulińska-Litewka, Joanna, & Laidler, Piotr, & D'Assoro, Antonino B., & Drobot, Lyudmyla B., & Umezawa, Kazuo, & Montalto, Giuseppe, & Cervello, Melchiorre, & Demidenko, Zoya N.. (December 2012). Advances in Targeting Signal Transduction Pathways. Oncotarget, (3:12), p.1505-1521. Retrieved from http://hdl.handle.net/10342/5672

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MLA:
McCubrey, James A., and Steelman, Linda S., and Chappell, William H., and Sun, Lin, and Davis, Nicole Marie, and Abrams, Stephen L., and Franklin, Richard A., and Cocco, Lucio, and Evangelisti, Camilla, and Chiarini, Francesca, and Martelli, Alberto M., and Libra, Massimo, and Candido, Saverio, and Ligresti, Giovanni, and Malaponte, Graziella, and Mazzarino, Maria C., and Fagone, Paolo, and Donia, Marco, and Nicoletti, Ferdinando, and Polesel, Jerry, and Talamini, Renato, and Bäsecke, Jörg, and Mijatovic, Sanja, and Maksimovic-Ivanic, Danijela, and Milella, Michele, and Tafuri, Agostino, and Dulińska-Litewka, Joanna, and Laidler, Piotr, and D'Assoro, Antonino B., and Drobot, Lyudmyla B., and Umezawa, Kazuo, and Montalto, Giuseppe, and Cervello, Melchiorre, and Demidenko, Zoya N.. "Advances in Targeting Signal Transduction Pathways". Oncotarget. 3:12. (1505-1521.), December 2012. October 24, 2020. http://hdl.handle.net/10342/5672.
Chicago:
McCubrey, James A. and Steelman, Linda S. and Chappell, William H. and Sun, Lin and Davis, Nicole Marie and Abrams, Stephen L. and Franklin, Richard A. and Cocco, Lucio and Evangelisti, Camilla and Chiarini, Francesca and Martelli, Alberto M. and Libra, Massimo and Candido, Saverio and Ligresti, Giovanni and Malaponte, Graziella and Mazzarino, Maria C. and Fagone, Paolo and Donia, Marco and Nicoletti, Ferdinando and Polesel, Jerry and Talamini, Renato and Bäsecke, Jörg and Mijatovic, Sanja and Maksimovic-Ivanic, Danijela and Milella, Michele and Tafuri, Agostino and Dulińska-Litewka, Joanna and Laidler, Piotr and D'Assoro, Antonino B. and Drobot, Lyudmyla B. and Umezawa, Kazuo and Montalto, Giuseppe and Cervello, Melchiorre and Demidenko, Zoya N., "Advances in Targeting Signal Transduction Pathways," Oncotarget 3, no. 12 (December 2012), http://hdl.handle.net/10342/5672 (accessed October 24, 2020).
AMA:
McCubrey, James A., Steelman, Linda S., Chappell, William H., Sun, Lin, Davis, Nicole Marie, Abrams, Stephen L., Franklin, Richard A., Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M., Libra, Massimo, Candido, Saverio, Ligresti, Giovanni, Malaponte, Graziella, Mazzarino, Maria C., Fagone, Paolo, Donia, Marco, Nicoletti, Ferdinando, Polesel, Jerry, Talamini, Renato, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Dulińska-Litewka, Joanna, Laidler, Piotr, D'Assoro, Antonino B., Drobot, Lyudmyla B., Umezawa, Kazuo, Montalto, Giuseppe, Cervello, Melchiorre, Demidenko, Zoya N.. Advances in Targeting Signal Transduction Pathways. Oncotarget. December 2012; 3(12) 1505-1521. http://hdl.handle.net/10342/5672. Accessed October 24, 2020.
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