KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain

Thumbnail
View/ Open

Show full item record

Author
Hussein, Hosni Ahmed Mohamed; Walker, Lia R.; Akula, Shaw M.
Abstract
Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, KSHV gB is the only glycoprotein known to possess the RGD (Arg-Gly-Asp) binding integrin domain critical to mediating cell attachment. Recent studies described gB to also possess a disintegrin-like domain (DLD) said to interact with non-RGD binding integrins. We wanted to decipher the roles of two individually distinct integrin binding domains (RGD versus DLD) within KSHV gB in regulating attachment of cells over cell migration.
URI
http://hdl.handle.net/10342/5684
Date
2016-02
Citation:
APA:
Hussein, Hosni Ahmed Mohamed, & Walker, Lia R., & Akula, Shaw M.. (February 2016). KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain. BMC Cancer, (1-17. Retrieved from http://hdl.handle.net/10342/5684

Display/Hide MLA, Chicago and APA citation formats.

MLA:
Hussein, Hosni Ahmed Mohamed, and Walker, Lia R., and Akula, Shaw M.. "KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain". BMC Cancer. . (1-17.), February 2016. October 30, 2020. http://hdl.handle.net/10342/5684.
Chicago:
Hussein, Hosni Ahmed Mohamed and Walker, Lia R. and Akula, Shaw M., "KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain," BMC Cancer 16, no. (February 2016), http://hdl.handle.net/10342/5684 (accessed October 30, 2020).
AMA:
Hussein, Hosni Ahmed Mohamed, Walker, Lia R., Akula, Shaw M.. KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain. BMC Cancer. February 2016; 16() 1-17. http://hdl.handle.net/10342/5684. Accessed October 30, 2020.
Collections