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    KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain

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    Author
    Hussein, Hosni Ahmed Mohamed; Walker, Lia R.; Akula, Shaw M.
    Abstract
    Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, KSHV gB is the only glycoprotein known to possess the RGD (Arg-Gly-Asp) binding integrin domain critical to mediating cell attachment. Recent studies described gB to also possess a disintegrin-like domain (DLD) said to interact with non-RGD binding integrins. We wanted to decipher the roles of two individually distinct integrin binding domains (RGD versus DLD) within KSHV gB in regulating attachment of cells over cell migration.
    URI
    http://hdl.handle.net/10342/5684
    Date
    2016-02
    Citation:
    APA:
    Hussein, Hosni Ahmed Mohamed, & Walker, Lia R., & Akula, Shaw M.. (February 2016). KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain. BMC Cancer, (1-17. Retrieved from http://hdl.handle.net/10342/5684

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Hussein, Hosni Ahmed Mohamed, and Walker, Lia R., and Akula, Shaw M.. "KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain". BMC Cancer. . (1-17.), February 2016. April 21, 2021. http://hdl.handle.net/10342/5684.
    Chicago:
    Hussein, Hosni Ahmed Mohamed and Walker, Lia R. and Akula, Shaw M., "KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain," BMC Cancer 16, no. (February 2016), http://hdl.handle.net/10342/5684 (accessed April 21, 2021).
    AMA:
    Hussein, Hosni Ahmed Mohamed, Walker, Lia R., Akula, Shaw M.. KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain. BMC Cancer. February 2016; 16() 1-17. http://hdl.handle.net/10342/5684. Accessed April 21, 2021.
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