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    Recent discoveries in the cycling, growing and aging of the p53 field

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    Author
    McCubrey, James A.; Demidenko, Zoya N.
    Abstract
    The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest.
    URI
    http://hdl.handle.net/10342/5698
    Subject
     cancer; aging; MTOR; TOR; longevity 
    Date
    2012-12
    Citation:
    APA:
    McCubrey, James A., & Demidenko, Zoya N.. (December 2012). Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY), (4:12), p.887-893. Retrieved from http://hdl.handle.net/10342/5698

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    McCubrey, James A., and Demidenko, Zoya N.. "Recent discoveries in the cycling, growing and aging of the p53 field". Aging (Albany NY). 4:12. (887-893.), December 2012. August 11, 2022. http://hdl.handle.net/10342/5698.
    Chicago:
    McCubrey, James A. and Demidenko, Zoya N., "Recent discoveries in the cycling, growing and aging of the p53 field," Aging (Albany NY) 4, no. 12 (December 2012), http://hdl.handle.net/10342/5698 (accessed August 11, 2022).
    AMA:
    McCubrey, James A., Demidenko, Zoya N.. Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY). December 2012; 4(12) 887-893. http://hdl.handle.net/10342/5698. Accessed August 11, 2022.
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