Recent discoveries in the cycling, growing and aging of the p53 field
Author
McCubrey, James A.; Demidenko, Zoya N.
Abstract
The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest.
Date
2012-12
Citation:
APA:
McCubrey, James A., & Demidenko, Zoya N.. (December 2012).
Recent discoveries in the cycling, growing and aging of the p53 field.
Aging (Albany NY),
4(12),
887-
893. Retrieved from
http://hdl.handle.net/10342/5698
MLA:
McCubrey, James A., and Demidenko, Zoya N..
"Recent discoveries in the cycling, growing and aging of the p53 field". Aging (Albany NY).
4:12. (887-893),
December 2012.
November 30, 2023.
http://hdl.handle.net/10342/5698.
Chicago:
McCubrey, James A. and Demidenko, Zoya N.,
"Recent discoveries in the cycling, growing and aging of the p53 field," Aging (Albany NY) 4, no.
12 (December 2012),
http://hdl.handle.net/10342/5698 (accessed
November 30, 2023).
AMA:
McCubrey, James A., Demidenko, Zoya N..
Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY).
December 2012;
4(12):
887-893.
http://hdl.handle.net/10342/5698. Accessed
November 30, 2023.
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