Browsing Biology by Title
Now showing items 981-1000 of 1310
-
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
(East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ... -
The Role of GSK-3[beta] in MCF-7 Breast Cancer Cell Signaling and Drug Resistance
(East Carolina University, 2011)Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of critical cellular processes. This versatile protein is involved in numerous signaling pathways that influence metabolism, ... -
The Role of Mitochondrial Biogenesis in Human Mesenchymal Stem Cell Differentiation and Acquisition of a Cardiac Phenotype
(East Carolina University, 2013)Introduction: With an increased understanding of myocardial infarction, human mesenchymal stem cell (hMSC) transplantation therapies have shown promising results as a possible treatment for heart failure. However, little ... -
THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
(East Carolina University, 2010)Tumor vascularization is an important control point in cancer progression and its inhibition is a promising approach to cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for ... -
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ... -
Root parasitic plant and shoot parasitic plant obtained Brassicaceae-specific genes by horizontal gene transfer
(2014)Background Besides gene duplication and de novo gene generation, horizontal gene transfer (HGT) is another important way of acquiring new genes. HGT may endow the recipients with novel phenotypic traits that are important ... -
S.O.S.
(2012-12)The concept that type 2 diabetes mellitus (T2DM) can be reversed with an intestinal operation is counterintuitive. How could our costliest disease be forced into full, durable, and safe remission with the bypass of a few ... -
SALINIZATION IMPACTS ON HISTORICALLY FRESHWATER BACTERIAL COMMUNITIES
(East Carolina University, 2017-12-15)Microorganisms regulate the movement of energy and nutrients through ecosystems. When environmental changes influence the composition of microbial communities, associated biogeochemical cycles can change in potentially ... -
SALT MARSH MOSQUITO DITCH ALTERATIONS: ECOLOGICAL IMPACTS AND PERSPECTIVES IN MANAGEMENT DECISIONS
(East Carolina University, 2018-12-10)Salt marsh ecosystems are prized for the numerous ecological and economic services that benefit society. On the U.S. east coast, virtually all salt marsh habitat from Maine to Virginia has been hydrologically degraded by ... -
The scale and evolutionary significance of horizontal gene transfer in the choanoflagellate
(2013-10)Background It is generally agreed that horizontal gene transfer (HGT) is common in phagotrophic protists. However, the overall scale of HGT and the cumulative impact of acquired genes on the evolution of these organisms ...