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Characterization of the GINS subunit psf1 in Drosophila Melanogaster
(East Carolina University, 2010)
GINS (Go Ichi Ni San; 5,1,2,3 in Japanese) is a heterotetrameric protein complex known to be essential for the establishment of DNA replication forks and the progression of the replisome. The GINS complex is known to be ...
Characterization of Site-Directed Mutants in the Cytochrome c-550 Protein of Photosystem II
(East Carolina University, 2010)
Photosynthesis is the process by which cyanobacteria, algae, and higher plants convert light energy to chemical energy via the biosynthesis of carbohydrates. Photosystem II is a multi-protein/pigment complex embedded in ...
Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
(East Carolina University, 2010)
Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ...
PROLACTIN FUNCTION IN ZEBRAFISH DEVELOPMENT
(East Carolina University, 2010)
Extensive studies have implicated a myriad of functional roles for prolactin (PRL) and prolactin receptor (PRLR) across a variety of adult vertebrate species. However, much less is known about the physiological role(s) of ...
Characterization of Extracellular Polymeric Substances from Acidophilic Microbial Biofilms
(East Carolina University, 2010-05)
We examined the chemical composition of extracellular polymeric substances (EPS) extracted from two natural microbial pellicle biofilms growing on acid mine drainage (AMD) solutions. The EPS obtained from a mid-developmental-stage ...
Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells
(East Carolina University, 2010)
DNA-dependent protein kinase (DNA-PK) is a holoenzyme of three subunits, Ku70, Ku80, and the DNA-Pk catalytic subunit (DNA-PKcs). DNA-PK serves a role in non-homologous end joining to repair double stranded breaks, and ...
Acute effects of fine particulate air pollution on ST segment height: A longitudinal study
(2010)
Background
The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms.
...
Connecting Mutations of the RNA Polymerase II C-Terminal Domain to Complex Phenotypic Changes Using Combined Gene Expression and Network Analyses
(2010)
The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. ...
Deep sequencing identifies novel and conserved microRNAs in peanuts (L.)
(2010)
Background
MicroRNAs (miRNAs) are a new class of small, endogenous RNAs that play a regulatory role in the cell by negatively affecting gene expression at the post-transcriptional level. miRNAs have been shown to control ...
Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective
(2010)
Background
There is very small occurrence of adenocarcinoma in the small bowel. We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the ...