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Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
(East Carolina University, 2012)
Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ...
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
(East Carolina University, 2012)
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ...
Historical Ecology of Striped Bass Stocking in the Southeastern United States
(East Carolina University, 2012)
Striped bass (Morone saxatilis) is the most recreationally and commercially important non-salmonid fish species in the continental United States. As such, it has been exploited to the point of collapse at various points ...
Conspicuous female ornamentation and male mate preference of Threespine Sticklebacks (Gasterosteus aculeatus)
(East Carolina University, 2012)
Sexual selection drives the evolution of exaggerated male ornaments (traits showing little function outside social interactions) in many animal species. Female ornamentation is now acknowledged also to be common but is ...
Lateral Gene Transfer between Bacteria and Trichoderma reesei
(East Carolina University, 2012)
Lateral gene transfer (LGT) has played an important role in shaping the `tree of life'. It has promoted evolution by generating gene redundancies, which allow for more freedom in terms of allowed mutations in a genome, ...
Analysis of Complex DNA Damage Associated with Tumor Growth
(East Carolina University, 2012)
The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ...
River Herring Nursery Habitat in Albemarle Sound, North Carolina, Inferred from Otolith Microchemistry
(East Carolina University, 2012)
River herring is a collective term used to describe two similar alosine species: alewife Alosa pseudoharengus and blueback herring A. aestivalis. Both of these anadromous species are native to the Atlantic coast of North ...
A Functional Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2012)
MicroRNAs (miRNAs) are a newly discovered class of endogenous post-transcriptional gene regulators that are typically 20-22 nucleotides in length that do not code for proteins. MiRNAs regulate gene expression by either ...
BIPARENTAL CARE AND THE EVOLUTION OF MONOGAMY IN A PERUVIAN POISON FROG (RANITOMEYA IMITATOR: DENDROBATIDAE)
(East Carolina University, 2012)
Selection for biparental care is considered to be an important factor in the evolution of monogamy if the value of exclusive cooperation in care for mutual offspring outweighs the benefits of polygamy for either sex. ...
CaMKII Protein Expression and Phosphorylation in Mouse Skeletal Muscle Following Atrophy and Hypertrophy
(East Carolina University, 2012)
The maintenance of skeletal muscle mass is vital for life, and elucidation of the molecular mechanisms that control this process is a critical first step towards the development of pharmaceutical treatments for muscle ...