Now showing items 1-5 of 5
Functional Unit of the RNA Polymerase II C-Terminal Domain Lies within Heptapeptide PairsÂ
(East Carolina University, 2004-06)
Unlike all other RNA polymerases, the largest subunit (RPB1) of eukaryotic DNA-dependent RNA polymerase II (RNAP II) has a C-terminal domain (CTD) comprising tandemly repeated heptapeptides with the consensus sequence ...
Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution
(East Carolina University, 2004-01)
The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish possess duplicated Hox ...
Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs
(East Carolina University, 2004-09-20)
Background: Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription. Among the ...
Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells
(East Carolina University, 2004)
Clustered DNA damages—two or more lesions on opposing strands and within one or two helical turns—are formed in cells by ionizing radiation or radiomimetic antitumordrugs. They are hypothesized to be difficult to repair, ...
Catabolite repression control (Crc) gene and Pseudomonas virulence
The present invention relates to a method of screening for compounds that inhibit the virulence of Pseudomonas bacteria and comprises the steps of: providing a culture medium comprising Pseudomonas bacteria, administering ...