Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness
Author
Soderstrom, Ken; Poklis, Justin L; Lichtman, Aron H
Abstract
Background
Previously we have found that cannabinoid treatment of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. Such persistently altered behavior must be attributable to changes in physiological substrates responsible for song. We are currently working to identify the nature of such physiological changes, and to understand how they contribute to altered vocal learning. One possibility is that developmental agonist exposure results in altered expression of elements of endocannabinoid signaling systems. To test this hypothesis we have studied effects of the potent cannabinoid receptor agonist WIN55212-2 (WIN) on endocannabinoid levels and densities of CB1 immunostaining in zebra finch brain.
Results
We found that late postnatal WIN treatment caused a long-term global disregulation of both levels of the endocannabinoid, 2-arachidonyl glycerol (2-AG) and densities of CB1 immunostaining across brain regions, while repeated cannabinoid treatment in adults produced few long-term changes in the endogenous cannabinoid system.
Conclusions
Our findings indicate that the zebra finch endocannabinoid system is particularly sensitive to exogenous agonist exposure during the critical period of song learning and provide insight into susceptible brain areas.
Date
2011
Citation:
APA:
Soderstrom, Ken, & Poklis, Justin L, & Lichtman, Aron H. (January 2011).
Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness.
BMC Neuroscience,
12(),
3-
3. Retrieved from
http://hdl.handle.net/10342/5764
MLA:
Soderstrom, Ken, and Poklis, Justin L, and Lichtman, Aron H.
"Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness". BMC Neuroscience.
12:. (3-3),
January 2011.
December 06, 2023.
http://hdl.handle.net/10342/5764.
Chicago:
Soderstrom, Ken and Poklis, Justin L and Lichtman, Aron H,
"Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness," BMC Neuroscience 12, no.
(January 2011),
http://hdl.handle.net/10342/5764 (accessed
December 06, 2023).
AMA:
Soderstrom, Ken, Poklis, Justin L, Lichtman, Aron H.
Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. BMC Neuroscience.
January 2011;
12():
3-3.
http://hdl.handle.net/10342/5764. Accessed
December 06, 2023.
Collections