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    Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates

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    Author
    Wang, XiaoJia; Reece, Shaun; Olmstead, Stephen; Wardle, Robert L; Van Scott, Michael R
    Abstract
    Nocturnal bronchoconstriction is a common symptom of asthma in humans, but is poorly documented in animal models. Thoracoabdominal asynchrony (TAA) is a noninvasive clinical indication of airway obstruction. In this study, respiratory inductive plethysmography (RIP) was used to document nocturnal TAA in house dust mite (HDM)-sensitive Cynomolgus macaques. Dynamic compliance (Cdyn) and lung resistance (RL) measured in anesthetized animals at rest and following exposure to HDM allergen, methacholine, and albuterol were highly correlated with three RIP parameters associated with TAA, ie, phase angle of the rib cage and abdomen waveforms (PhAng), baseline effort phase relation (eBPRL) and effort phase relation (ePhRL). Twenty-one allergic subjects were challenged with HDM early in the morning, and eBPRL and ePhRL were monitored for 20 hours after provocation. Fifteen of the allergic subjects exhibited gradual increases in eBPRL and ePhRL between midnight and 6 am, with peak activity at 4 am. However, as in humans, this nocturnal response was highly variable both between subjects and within subjects over time. The results document that TAA in this nonhuman primate model of asthma is highly correlated with Cdyn and RL, and demonstrate that animals exhibiting acute responses to allergen exposure during the day also exhibit nocturnal TAA.
    URI
    http://hdl.handle.net/10342/5776
    Subject
     nocturnal asthma; late phase asthmatic response; respiratory inductive plethysmography 
    Date
    2010
    Citation:
    APA:
    Wang, XiaoJia, & Reece, Shaun, & Olmstead, Stephen, & Wardle, Robert L, & Van Scott, Michael R. (January 2010). Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates. Journal of asthma and allergy, (75-86. Retrieved from http://hdl.handle.net/10342/5776

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Wang, XiaoJia, and Reece, Shaun, and Olmstead, Stephen, and Wardle, Robert L, and Van Scott, Michael R. "Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates". Journal of asthma and allergy. . (75-86.), January 2010. March 03, 2021. http://hdl.handle.net/10342/5776.
    Chicago:
    Wang, XiaoJia and Reece, Shaun and Olmstead, Stephen and Wardle, Robert L and Van Scott, Michael R, "Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates," Journal of asthma and allergy 3, no. (January 2010), http://hdl.handle.net/10342/5776 (accessed March 03, 2021).
    AMA:
    Wang, XiaoJia, Reece, Shaun, Olmstead, Stephen, Wardle, Robert L, Van Scott, Michael R. Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates. Journal of asthma and allergy. January 2010; 3() 75-86. http://hdl.handle.net/10342/5776. Accessed March 03, 2021.
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