• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Health Sciences Campus
    • Brody School of Medicine
    • Physiology
    • View Item
    •   ScholarShip Home
    • Health Sciences Campus
    • Brody School of Medicine
    • Physiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner

    Thumbnail
    View/ Open
    1743-8977-7-9.PMC2861012.pdf (2.211Mb)

    Show full item record
    Author
    Rondini, Elizabeth A.; Walters, Dianne M.; Bauer, Alison K.
    Abstract
    Background Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic development through the induction of oxidative stress and inflammation, a lung cancer risk factor. Vanadium pentoxide (V2O5) is a component of PM derived from fuel combustion as well as a source of occupational exposure in humans. In the current investigation we examined the influence of genetic background on susceptibility to V2O5-induced inflammation and evaluated whether V2O5 functions as a tumor promoter using a 2-stage (initiation-promotion) model of pulmonary neoplasia in mice. Results A/J, BALB/cJ (BALB), and C57BL/6J (B6) mice were treated either with the initiator 3-methylcholanthrene (MCA; 10 μg/g; i.p.) or corn oil followed by 5 weekly aspirations of V2O5 or PBS and pulmonary tumors were enumerated 20 weeks following MCA treatment. Susceptibility to V2O5-induced pulmonary inflammation was assessed in bronchoalveolar lavage fluid (BALF), and chemokines, transcription factor activity, and MAPK signaling were quantified in lung homogenates. We found that treatment of animals with MCA followed by V2O5 promoted lung tumors in both A/J (10.3 ± 0.9 tumors/mouse) and BALB (2.2 ± 0.36) mice significantly above that observed with MCA/PBS or V2O5 alone (P < 0.05). No tumors were observed in the B6 mice in any of the experimental groups. Mice sensitive to tumor promotion by V2O5 were also found to be more susceptible to V2O5-induced pulmonary inflammation and hyperpermeability (A/J>BALB>B6). Differential strain responses in inflammation were positively associated with elevated levels of the chemokines KC and MCP-1, higher NFκB and c-Fos binding activity, as well as sustained ERK1/2 activation in lung tissue. Conclusions In this study we demonstrate that V2O5, an occupational and environmentally relevant metal oxide, functions as an in vivo lung tumor promoter among different inbred strains of mice. Further, we identified a positive relationship between tumor promotion and susceptibility to V2O5-induced pulmonary inflammation. These findings suggest that repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
    URI
    http://hdl.handle.net/10342/5777
    Date
    2010
    Citation:
    APA:
    Rondini, Elizabeth A., & Walters, Dianne M., & Bauer, Alison K.. (January 2010). Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Particle and Fibre Toxicology, 7(), 9- 9. Retrieved from http://hdl.handle.net/10342/5777

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Rondini, Elizabeth A., and Walters, Dianne M., and Bauer, Alison K.. "Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner". Particle and Fibre Toxicology. 7:. (9-9), January 2010. September 23, 2023. http://hdl.handle.net/10342/5777.
    Chicago:
    Rondini, Elizabeth A. and Walters, Dianne M. and Bauer, Alison K., "Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner," Particle and Fibre Toxicology 7, no. (January 2010), http://hdl.handle.net/10342/5777 (accessed September 23, 2023).
    AMA:
    Rondini, Elizabeth A., Walters, Dianne M., Bauer, Alison K.. Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Particle and Fibre Toxicology. January 2010; 7(): 9-9. http://hdl.handle.net/10342/5777. Accessed September 23, 2023.
    Collections
    • Physiology

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback