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    Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy

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    Author
    O'Neal, Wesley T.; Griffin, William F.; Kent, Susan D.; Faiz, Filza; Hodges, Jonathan; Vuncannon, Jackson; Virag, Jitka A. I.
    Abstract
    EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused myocardial injury in vivo, infarct size, inflammatory cell density, NF-κB, p-AKT/Akt, and MMP-2 protein levels, and changes in ephrinA1/EphA2-R gene expression profile were assessed 4 days post-MI in B6129 wild-type (WT) and EphA2-R-mutant (EphA2-R-M) mice lacking a functional EphA2-R. Fibrosis, capillary density, morphometry of left ventricular chamber and infarct dimensions, and cardiac function also were measured 4 weeks post-MI to determine the extent of ventricular remodeling. EphA2-R-M infarct size and area of residual necrosis were 31.7% and 113% greater than WT hearts, respectively. Neutrophil and macrophage infiltration were increased by 46% and 84% in EphA2-R-M hearts compared with WT, respectively. NF-κB protein expression was 1.9-fold greater in EphA2-R-M hearts at baseline and 56% less NF-κB after infarction compared with WT. EphA6 gene expression was 2.5-fold higher at baseline and increased 9.8-fold 4 days post-MI in EphA2-R-M hearts compared with WT. EphrinA1 gene expression in EphA2-R-M hearts was unchanged at baseline and decreased by 42% 4 days post-MI compared with WT hearts. EphA2-R-M hearts had 66.7% less expression of total Akt protein and 59% less p-Akt protein than WT hearts post-MI. EphA2-R-M hearts 4 weeks post-MI had increased chamber dilation and interstitial fibrosis and decreased MMP-2 expression and capillary density compared with WT. In conclusion, the EphA2-R is necessary to appropriately modulate the inflammatory response and severity of early injury during acute MI, thereby influencing the progression of ischemic cardiomyopathy.
    URI
    http://hdl.handle.net/10342/5793
    Date
    2014-04
    Citation:
    APA:
    O'Neal, Wesley T., & Griffin, William F., & Kent, Susan D., & Faiz, Filza, & Hodges, Jonathan, & Vuncannon, Jackson, & Virag, Jitka A. I.. (April 2014). Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy. Frontiers in Physiology, (1-9. Retrieved from http://hdl.handle.net/10342/5793

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    MLA:
    O'Neal, Wesley T., and Griffin, William F., and Kent, Susan D., and Faiz, Filza, and Hodges, Jonathan, and Vuncannon, Jackson, and Virag, Jitka A. I.. "Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy". Frontiers in Physiology. . (1-9.), April 2014. August 10, 2022. http://hdl.handle.net/10342/5793.
    Chicago:
    O'Neal, Wesley T. and Griffin, William F. and Kent, Susan D. and Faiz, Filza and Hodges, Jonathan and Vuncannon, Jackson and Virag, Jitka A. I., "Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy," Frontiers in Physiology 5, no. (April 2014), http://hdl.handle.net/10342/5793 (accessed August 10, 2022).
    AMA:
    O'Neal, Wesley T., Griffin, William F., Kent, Susan D., Faiz, Filza, Hodges, Jonathan, Vuncannon, Jackson, Virag, Jitka A. I.. Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy. Frontiers in Physiology. April 2014; 5() 1-9. http://hdl.handle.net/10342/5793. Accessed August 10, 2022.
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