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    Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?

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    Author
    Alleman, Rick J.; Stewart, Luke M.; Tsang, Alvin M.; Brown, David A.
    Abstract
    Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that exercise, specifically characterized by lower myocardial infarction and arrhythmia. Despite the clear benefits, the underlying cellular and molecular mechanisms that are responsible for exercise preconditioning are not fully understood. In particular, the adaptive signaling events that occur during exercise to “trigger” cardioprotection represent emerging paradigms. In this review, we discuss recent studies that have identified several different factors that appear to initiate exercise preconditioning. We summarize the evidence for and against specific cellular factors in triggering exercise adaptations and identify areas for future study.
    URI
    http://hdl.handle.net/10342/5794
    Subject
     Preconditioning; cardiac; mitochondria; exercise; heart 
    Date
    2015-05
    Citation:
    APA:
    Alleman, Rick J., & Stewart, Luke M., & Tsang, Alvin M., & Brown, David A.. (May 2015). Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?. Dose-Response, 13(1), 1- Response; 13:1 p. 1-19. Retrieved from http://hdl.handle.net/10342/5794

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Alleman, Rick J., and Stewart, Luke M., and Tsang, Alvin M., and Brown, David A.. "Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?". Dose-Response. 13:1. (1-19), May 2015. September 26, 2023. http://hdl.handle.net/10342/5794.
    Chicago:
    Alleman, Rick J. and Stewart, Luke M. and Tsang, Alvin M. and Brown, David A., "Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?," Dose-Response 13, no. 1 (May 2015), http://hdl.handle.net/10342/5794 (accessed September 26, 2023).
    AMA:
    Alleman, Rick J., Stewart, Luke M., Tsang, Alvin M., Brown, David A.. Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?. Dose-Response. May 2015; 13(1): 1-19. http://hdl.handle.net/10342/5794. Accessed September 26, 2023.
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