Browsing Chemistry by Title
Now showing items 8-27 of 120
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A Calorimetric and Spectroscopic Study of the Interactions Between Model Lipid Membrane Bilayers and Simple Sugars
(East Carolina University, 2015)It is well known that various organisms, such as the tardigrade, naturally use carbohydrates, particularly disaccharides, to help preserve their cell structural and functional integrity during freezing or dehydration. There ... -
Computational Investigation of Calcium Binding Proteins Annexin A1 and Cardiac Troponin C
(East Carolina University, 2019-07-15)Calcium binding proteins are vital for many biological functions. Many undergo calcium induced conformation changes through sensing motifs, resulting in functional changes for the proteins. In this study computational ... -
Conservation of Archaeological Wood using Non-Reducing sugars
(2015)In the conservation field there are many different thoughts on the best way to conserve waterlogged archaeological wood. The current method uses polyethylene glycol(PEG), a hydrophilic organic compound, to replace water ... -
Counting Protons: Using Isothermal Titration Calorimetry to Determine the Number of Protons Exchanged Upon Ca(II) and Cd(II) Binding to Wild-type HcTnC and Mutant C84A and C35A/C84A Proteins
(East Carolina University, 2018-07-20)Maintaining a delicate balance of metal ions in the cell is crucial to the survival of many organisms. Divalent cadmium, Cd(II), is a non-essential metal ion that can disrupt this delicate balance and lead to deleterious ... -
Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
(East Carolina University, 2012)Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ... -
Defining Protein Motions the Comprise the Reaction Barrier in Human Epithelial 15-Lipoxygenase-2
(East Carolina University, 2022-04-27)Proteins are dynamic in nature, with these motions playing a role in substrate binding and product release. Protein thermal motions have emerged as participating in the bond making/breaking steps of catalysis and by extension ... -
Defining the Role of the C-Terminal Region of Troponin T by Analysis of a Series of Truncation Mutants
(East Carolina University, 2016-07-21)Familial hypertrophic cardiomyopathy and other cardiovascular diseases result from mutations of any of the contractile proteins. Mutations within the actin binding regulatory complex of proteins, including tropomyosin (Tm) ... -
Design and Quantitation of Membrane Binding Lipid Anchors : Exploring Prion-Prion Interactions on Membrane Surfaces
(East Carolina University, 2011)The prion protein (PrP) is an endogenous, metal binding protein present in the neuronal cells of the central nervous system. Prion is associated with a class of neurodegenerative diseases known as transmissible spongiform ... -
Detection of Environmental DNA Damage Using Electrochemical Sensors and Mass Spectrometry
(East Carolina University, 2018-05-04)Nickel exposure has been linked to a variety of health complications including instances of tumors and cancer in living organisms. Exposure to nickel can occur due to pollution from mining or industrial applications. ... -
Developing Novel Chemotherapeutics: A Structure-Activity Study of Anandamide Analogs and their Cytotoxic Profiles
(East Carolina University, 2020-01-06)Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzyme responsible for both the metabolism of arachidonic acid (AA) to prostaglandins and arachidonoyl ethanolamine (AEA) to ... -
Development of Green Subcritical Water Separation Technology
(East Carolina University, 2019-08-19)Theoretically speaking, water under temperature and pressure conditions below its critical point is called subcritical water. However, the term “subcritical water” normally refers to hot water up to 374 C and pressure up ... -
DEVELOPMENT OF UNNATURAL SUBSTRATES AND TRYPTOPHAN AMINO ACIDS TO STUDY PROTON COUPLED ELECTRON TRANSFER IN ENZYMES
(East Carolina University, 2020-12-09)Proton-coupled electron transfer plays an important role in substrate oxidation by C-H bond cleavage and long-range pathways associated with bioenergetics. This thesis is focused on the synthesis of unnatural substrates ... -
DIFFERENTIATION OF J-SERIES PROSTAGLANDINS AS PRO-APOPTOTIC PRODUCTS OF CANCER CELL METABOLISM
(East Carolina University, 2016-12-16)Cyclopentenone J-series prostaglandins and prostaglandin-ethanolamide conjugates have been shown to selectively induce endoplasmic reticulum stress-apoptosis in different cancer cell types. These lipids have been identified ... -
DIRECT ELECTROCHEMICAL ANALYSIS OF THE REDOX ACTIVITY OF TRYPTOPHAN AND TYROSINE IN MODIFIED AZURINS: THE IMPACT OF THE PROTEIN ENVIRONMENT
(East Carolina University, 2021-05-03)Proton-coupled electron transfer (PCET) is a biological process essential to life. It is imperative for respiration in animals as well as photosynthesis in plants. Long-range PCET is often facilitated by redox-active amino ...