Browsing Chemistry by Title
Now showing items 2-21 of 32
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Design and Quantitation of Membrane Binding Lipid Anchors : Exploring Prion-Prion Interactions on Membrane Surfaces
(East Carolina University, 2011)The prion protein (PrP) is an endogenous, metal binding protein present in the neuronal cells of the central nervous system. Prion is associated with a class of neurodegenerative diseases known as transmissible spongiform ... -
DISNET: a Distributed Instrument System NETwork
(East Carolina University, 1984) -
DISNET: a Distributed System NETwork
(East Carolina University, 1984)This paper describes a Distributed Instrument System NETwork (DISNET) which was implemented within the Department of Chemistry at Cleveland State University. -
The Duff Reaction: Researching A Modification
(2014)Formylation reactions are used to synthesize aldehydes. The Duff reaction is a formylation reaction that uses phenol derivatives, hexamethylenetetramine, acetic acid, and acid to synthesis ortho substituted aromatic ... -
ELECTROCHEMICAL DETECTION OF BENZO[A]PYRENE METABOLITE DNA DAMAGE : IMPLICATIONS OF NUCLEOBASE SEQUENCE AND ADDUCT STEREOCHEMISTRY
(East Carolina University, 2011)Xenobiotics are chemical compounds introduced to living organisms that originate outside the body. A well-studied xenobiotic is benzo[a]pyrene (BP), a polyaromatic hydrocarbon (PAH) primarily introduced into the body via ... -
ELECTROSPRAY IONIZATION TIME OF FLIGHT MASS SPECTROMETRY OF POLY(METHYL METHACRYLATE) AND POLYSTYRENE USING SURFACE ACTIVE QUATERNARY AMMONIUM SALTS
(East Carolina University, 2011)Electrospray ionization time of flight mass spectrometry (ESI-ToF-MS) is a powerful characterization technique for large nonvolatile compounds, but has found limited applicability in the synthetic polymer field. Two factors ... -
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ... -
Extraction of Salvia miltiorrhiza Using Subcritical Water
(2014)Salvia miltiorrhiza, also known as Danshen, is an herb commonly used in Chinese medicine to treat cardiovascular and other diseases. As it has recently gained more recognition, this herb is currently being investigated for ... -
A flexible computer-to-computer protocol for DISNET: a Distributed Instrument System NETwork
(East Carolina University, 1984)This article evaluates the performance of a DISNET channel control module. -
Identification of Damaged DNA Adducts from Exposure to Benzo[a]pyrene in the TP53 Gene
(2015)Benzo[a]pyrene is a carcinogen associated with tobacco smoke that can damage DNA after it is metabolized into highly reactive forms. Identifying the resulting DNA adducts can give greater insight into the mutations that ... -
Identification of the Cu(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Cu(II) Loadings
(East Carolina University, 2008-09-02)While the Cu(II) binding sites of the prion protein have been well studied under Cu-saturation conditions, the identity of the residues involved in coordinating Cu(II) at low stoichiometries and the order in which the ... -
The implementation of a GC/MS data system using DISNET: a Distributed Instrument System NETwork
(East Carolina University, 1984) -
The implementation of a GC/MS data system using DISNET: a Distributed Instrument System NETwork
(East Carolina University, 1984)The primary goal of a computer network is to achieve resource sharing between several computers. Resource sharing is most easily performed at the application program level, with lower layers of software providing communications ... -
Improving the Reliability of Peptide-Zinc (II) Binding Constant Determination with Mass Spectrometry
(East Carolina University, 2012)Electrospray Ionization Mass Spectrometry (ESI-MS) has become a powerful technique for analyzing protein- and peptide-ligand interactions and quantifying their binding constants (K[subscript]b). However, ESI-MS as an ... -
Insight Into the Location of DNA Xenobiotic Damage by Mass Spectrometry
(2014)Damage to DNA by a bioactivated xenobiotic typically occurs at specific sites within the genome, called hotspots. An example of this is benzo[a]-pyrene (BP), a xenobiotic that enters the body via cigarette smoking. ... -
Investigation Into Intermolecular Interactions of Gd3N@C80(OH)n Using Fluorescence Spectroscopy
(2014)The aim of this experiment was to investigate the intermolecular interactions of the endohedral metallofulerene complex in water and various metal cation solutions. These interactions were observed using a methodology ... -
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
(East Carolina University, 2010)Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ... -
NMR Studies into the Potential Interactions of Fullerene C[subscript]60, with Tetraphenylporphyrin, H[subscript]2[TPP] and Some of its Derivatives
(East Carolina University, 2011)The curved [pi] surface of fullerene, C[subscript]60, shows a tendency to interact with other molecules, making it an interesting target for building supramolecular arrays. The interaction can be relative strong and may ... -
Oxidation of Isoprene to Methyl vinyl ketone and Methacrolein via Hydroxyl Radical : A Regenerative Mechanism for the Hydroxyl Radical
(East Carolina University, 2013)Isoprene is an important molecule in atmospheric chemistry. Belonging to a class of molecules known as volatile organic compounds, it undergoes reactions with several different oxidizers in the atmosphere, including ... -
Prothymosin-Alpha : Features of the protein sequence that contribute to the anti-HIV Activity
(East Carolina University, 2010)Prothymosin-alpha (ProT[alpha]) is a protein mainly located in the nucleus of the cells. Though its exact function is not known, it is believed to be involved in cell proliferation. The ability of this protein to inhibit ...