Browsing Chemistry by Title
Now showing items 76-95 of 116
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protaTETHER – a method for the incorporation of variable linkers in protein fusions reveals impacts of linker flexibility in a PKAc‐GFP fusion protein
(2018-03-14)Protein fusions are of fundamental importance in the study of cellular biology and the elucidation of cell signaling pathways, and the importance of linkers for the proper function of protein fusions is well documented in ... -
Prothymosin-Alpha : Features of the protein sequence that contribute to the anti-HIV Activity
(East Carolina University, 2010)Prothymosin-alpha (ProT[alpha]) is a protein mainly located in the nucleus of the cells. Though its exact function is not known, it is believed to be involved in cell proliferation. The ability of this protein to inhibit ... -
A quantitative and nondestructive method for determining the degradation of waterlogged archaeological wood
(East Carolina University, 2013)Archaeological artifacts are an essential part of preserving history and culture, and can be valuable tools for enhancing education and contributing economic benefits through tourism. Of the artifacts that one may encounter, ... -
Quinone Formation via Ceric Ammonium Nitrate Oxidations of 2-Alkyl-1,4-dialkoxybenzenes
(East Carolina University, 2016-05-03)Quinones are cyclohexadiendiones that have a variety of uses ranging from medical applications to synthetic building blocks. Medicinal applications stem from the potent biological activity (e.g. antitumor and antibiotic) ... -
Recognition of bacterial lipid headgroups by fluorescent crown ether-naphthalimides
(2015)The increasing incidence of antibiotic- resistant bacterial strains is a significant threat to human health. New antimicrobial mechanisms that feature reduced resistance potential are necessary to slow down the rapid ... -
SCREENING AND CHARACTERIZATION OF BIOCATALYSTS FOR SYNTHESIS OF WIELAND MIESCHER KETONE: A VERSATILE SYNTHETIC INTERMEDIATE
(East Carolina University, 2020-12-07)Biocatalysts derived from biological molecules such as proteins, RNA, and DNA have long been exploited for applications in synthetic chemistry. Lipases, a versatile class of biocatalysts, are known to exhibit significant ... -
SEPARATION AND ANALYSIS OF PRESERVATIVES IN SKINCARE CREAMS BY HIGH TEMPERATURE LIQUID CHROMATOGRAPHY AND SUBCRITICAL WATER CHROMATOGRAPHY
(East Carolina University, 2011)Preservatives are chemicals with antimicrobial activity commonly added to foods, pharmaceuticals and cosmetics in order to prolong products' shelf life and to protect the consumer from potential infection. Parabens, the ... -
Solvent and Solubility Effects on Quinone Ratios
(East Carolina University, 2012)Monoquinones and diquinones are a biologically and chemically important class of compounds that can be found in numerous natural products such as: thymoquinone, oosporein, coenzyme Q, embelin and the respective dimer, ... -
Solvent-Controlled Switch of Selectivity between sp[superscript]2 and s[superscript]p3 C-H Bond Activation by Platinum (II)
(East Carolina University, 2010)Cyclometalation reactions have been studied intensely for the past few decades, especially those containing palladium. The factors that control the process of the C-H bond activation, however, are not yet completely ... -
SPECTROSCOPIC INVESTIGATIONS OF BINDING MECHANISMS BETWEEN ANTIMICROBIAL PEPTIDES AND MODELS OF THE MEMBRANES OF PSEUDOMONAS AERUGINOSA AND KLEBSIELLA PNEUMONIAE
(East Carolina University, 2014)The wide application of antibiotics goes back over sixty years to the first use of penicillin in the mid-1940s. Antimicrobial agents have well-documented activity and have played a significant role in defending against ... -
STABILITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND BENZOIC ACID DERIVATIVES UNDER SUBCRITICAL WATER CONDITIONS
(East Carolina University, 2011)The development of green environmental remediation, chromatography, and extraction techniques using subcritical water is the focus of our research group. The polarity of subcritical water can be manipulated by increasing ... -
Studying Collagen with PyrATS: Pyrene-Appended Trimeric Systems
(East Carolina University, 2019-07-30)Collagens are a family of triple-helical structural proteins that are ubiquitous in vertebrates. Improper folding of collagen can lead to disorders such as osteogenesis imperfecta, or "brittle bone disease." There is ... -
Subcritical Water Extraction of Salvia miltiorrhiza
(2021-03-15) -
Surfactant Assisted Electrospray Ionization Time of Flight Mass Spectrometry of Synthetic Polymers
(East Carolina University, 2010)Synthetic polymers are complex mixtures which often require extensive characterization to determine chemical composition and structure. Mass spectrometric techniques have greatly enhanced the quantity, as well as the ... -
SYNTHESIS AND PHOTOPHYSICAL CHARACTERIZATION OF TRIDENTATE C^N*N PLATINUM (II) COMPLEXES and, INVESTIGATION OF SELECTIVITY IN C-H BOND ACTIVATION BY PLATINUM
(East Carolina University, 2012)The synthesis, structure, and photophysical properties of a series of novel, highly luminescent tridentate platinum complexes with general coordination geometry of (C^N*N)-PtL are reported, where "C^N" denotes a coordination ... -
Synthesis and Reactions of Novel Heteroarylzirconocene Reagents
(East Carolina University, 2012)The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerful and highly desirable transformation in both the synthesis of pharmaceutical compounds as well as materials development. ... -
SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF BOC- PROTECTED FLUORESCENT ARGININE
(East Carolina University, 2017-08-21)Small peptides capable of penetrating or spanning the hydrophobic core of lipid bilayers have many potential uses in medicine and in biochemical research. As the most basic of the amino acids that can comprise such peptides, ... -
Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
(East Carolina University, 2015)Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR serves to control the gradient of chloride and bicarbonate ions across the cellular ... -
Synthesis, structure, photophysics, and biological activity of platinum (II) complexes
(East Carolina University, 2013)The synthesis, structure, and photophysical properties of luminescent platinum (II) complexes with different coordination patterns, (C^C*N^N), (N^C*N), (N^N*C) and (N^N^C) are reported, where "C^N or N^N" denotes a bidentate ...