Browsing Chemistry by Author "Li, Yumin"
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Computational Investigation of Calcium Binding Proteins Annexin A1 and Cardiac Troponin C
Lewis, Kimberly A (East Carolina University, 2019-07-15)Calcium binding proteins are vital for many biological functions. Many undergo calcium induced conformation changes through sensing motifs, resulting in functional changes for the proteins. In this study computational ... -
Molecular Dynamics Studies of Point Mutations of Cardiac Troponin C and Annexin
Simpkins, Bradley (East Carolina University, 2015)Calcium binding proteins are biologically important for their ability to convert changes in calcium ion concentration to functional changes in proteins. All calcium binding proteins use a calcium sensing motif that changes ... -
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
Donohue, Matthew P. (East Carolina University, 2010)Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ... -
Theoretical Probe to the Mechanism of Pt-catalyzed C-H Acylation Reaction: Possible Pathways for the Key Acylation Reaction of Platinacycles
Warden, Elizabeth Fae (East Carolina University, 2019-08-23)Transition metal-catalyzed C-H bond functionalization offers a variety of desirable transformations of simple hydrocarbons to more complex compounds with applications being applied in pharmaceuticals to material sciences. ...