Browsing Chemistry by Author "Ohler, Amanda"
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Defining Protein Motions the Comprise the Reaction Barrier in Human Epithelial 15-Lipoxygenase-2
Ohler, Amanda (East Carolina University, 2022-04-27)Proteins are dynamic in nature, with these motions playing a role in substrate binding and product release. Protein thermal motions have emerged as participating in the bond making/breaking steps of catalysis and by extension ... -
Kinetic and Structural Investigations of Novel Inhibitors of Human Epithelial 15-Lipoxygenase-2
Ohler, Amanda; Offenbacher, Adam R.; Tsai, Wan-Chen; Gilbert, Nathaniel C.; Armstrong, Michelle; Perry, Steven; Kalyanaraman, Chakrapani; Yasgar, Adam; Rai, Ganesha; Simeonov, Anton; Jadhav, Ajit; Standley, Melissa; Lee, Hsiau-Wei; Crew, Phillip; Iavarone, Anthony T.; Jacobson, Matthew P.; Neau, David B.; Newcomer, Marcia; Holman, Theodore R. (2021)