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Elucidating "Consumption" : Using Fluorescent Steroid Probes to Understand Host Cholesterol Utilization by Mycobacterium spp.
(East Carolina University, 2014)
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, is the leading cause of death due to bacterial infection worldwide, claiming nearly two million lives each year. Often, the immune system ...
SPECTROSCOPIC INVESTIGATIONS OF BINDING MECHANISMS BETWEEN ANTIMICROBIAL PEPTIDES AND MODELS OF THE MEMBRANES OF PSEUDOMONAS AERUGINOSA AND KLEBSIELLA PNEUMONIAE
(East Carolina University, 2014)
The wide application of antibiotics goes back over sixty years to the first use of penicillin in the mid-1940s. Antimicrobial agents have well-documented activity and have played a significant role in defending against ...
Using Fluorescent Probes to Study the Location and Interaction of Disaccharides within Lipid Bilayers
(East Carolina University, 2016-04-26)
It is well known that certain organisms, such as the tardigrade, are capable of surviving extreme conditions including dehydration, freezing and / or oxygen deficiency. The tardigrades ability to withstand such extreme ...
Quinone Formation via Ceric Ammonium Nitrate Oxidations of 2-Alkyl-1,4-dialkoxybenzenes
(East Carolina University, 2016-05-03)
Quinones are cyclohexadiendiones that have a variety of uses ranging from medical applications to synthetic building blocks. Medicinal applications stem from the potent biological activity (e.g. antitumor and antibiotic) ...
Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
(East Carolina University, 2015)
Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR serves to control the gradient of chloride and bicarbonate ions across the cellular ...
Oxidation of Isoprene to Methyl vinyl ketone and Methacrolein via Hydroxyl Radical : A Regenerative Mechanism for the Hydroxyl Radical
(East Carolina University, 2013)
Isoprene is an important molecule in atmospheric chemistry. Belonging to a class of molecules known as volatile organic compounds, it undergoes reactions with several different oxidizers in the atmosphere, including ...
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
(East Carolina University, 2010)
Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ...
Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
(East Carolina University, 2010)
Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to ...