Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study

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Mitchell, James E.; King, Wendy C.; Chen, Jia-Yuh; Devlin, Michael J.; Flum, David; Garcia, Luis; Pender, John R.; Kalarchian, Melissa A.; Khandelwal, Saurabh; Marcus, Marsha D.; Schrope, Beth; Strain, Gladys; Wolfe, Bruce; Yanovski, Susan
Abstract
Objective To examine changes in depressive symptoms and treatment in the first three years following bariatric surgery. Design and Methods The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study of adults (n=2,458) who underwent a bariatric surgical procedure at one of ten US hospitals between 2006–9. This study includes 2,148 participants who completed the Beck Depression Inventory (BDI) at baseline and ≥ one follow-up visit in years 1–3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score≥10) were reported by 28.3%; moderate (BDI score 19–29) and severe (BDI score ≥30) symptoms were uncommon (4.2% and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR=1.75; p=.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1yr; 12.2%, 2yrs; 15.6%, 3yrs; ps<.001), but increased between 1 and 3 years postoperatively (p<.01). Change in depressive symptoms was significantly related to change in body mass index (r=.42; p<0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year.
URI
http://hdl.handle.net/10342/5854
Subject
 Roux-en-Y gastric bypass; laparoscopic adjustable gastric band; severe obesity; weight loss; treatment; depression; antidepressant medication 
Date
2014-05
Citation:
APA:
Mitchell, James E., & King, Wendy C., & Chen, Jia-Yuh, & Devlin, Michael J., & Flum, David, & Garcia, Luis, & Pender, John R., & Kalarchian, Melissa A., & Khandelwal, Saurabh, & Marcus, Marsha D., & Schrope, Beth, & Strain, Gladys, & Wolfe, Bruce, & Yanovski, Susan. (May 2014). Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study. Obesity (Silver Spring, Md.), 22(8), 1799- 1806. Retrieved from http://hdl.handle.net/10342/5854

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MLA:
Mitchell, James E., and King, Wendy C., and Chen, Jia-Yuh, and Devlin, Michael J., and Flum, David, and Garcia, Luis, and Pender, John R., and Kalarchian, Melissa A., and Khandelwal, Saurabh, and Marcus, Marsha D., and Schrope, Beth, and Strain, Gladys, and Wolfe, Bruce, and Yanovski, Susan. "Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study". Obesity (Silver Spring, Md.). 22:8. (1799-1806), May 2014. September 22, 2023. http://hdl.handle.net/10342/5854.
Chicago:
Mitchell, James E. and King, Wendy C. and Chen, Jia-Yuh and Devlin, Michael J. and Flum, David and Garcia, Luis and Pender, John R. and Kalarchian, Melissa A. and Khandelwal, Saurabh and Marcus, Marsha D. and Schrope, Beth and Strain, Gladys and Wolfe, Bruce and Yanovski, Susan, "Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study," Obesity (Silver Spring, Md.) 22, no. 8 (May 2014), http://hdl.handle.net/10342/5854 (accessed September 22, 2023).
AMA:
Mitchell, James E., King, Wendy C., Chen, Jia-Yuh, Devlin, Michael J., Flum, David, Garcia, Luis, Pender, John R., Kalarchian, Melissa A., Khandelwal, Saurabh, Marcus, Marsha D., Schrope, Beth, Strain, Gladys, Wolfe, Bruce, Yanovski, Susan. Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study. Obesity (Silver Spring, Md.). May 2014; 22(8): 1799-1806. http://hdl.handle.net/10342/5854. Accessed September 22, 2023.
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