Course of Depressive Symptoms and Treatment in the Longitudinal Assessment of Bariatric Surgery (LABS-2) Study
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Date
2014-05
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Authors
Mitchell, James E.
King, Wendy C.
Chen, Jia-Yuh
Devlin, Michael J.
Flum, David
Garcia, Luis
Pender, John R.
Kalarchian, Melissa A.
Khandelwal, Saurabh
Marcus, Marsha D.
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Abstract
Objective
To examine changes in depressive symptoms and treatment in the first three years following bariatric surgery.
Design and Methods
The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study of adults (n=2,458) who underwent a bariatric surgical procedure at one of ten US hospitals between 2006–9. This study includes 2,148 participants who completed the Beck Depression Inventory (BDI) at baseline and ≥ one follow-up visit in years 1–3.
Results
At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score≥10) were reported by 28.3%; moderate (BDI score 19–29) and severe (BDI score ≥30) symptoms were uncommon (4.2% and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR=1.75; p=.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1yr; 12.2%, 2yrs; 15.6%, 3yrs; ps<.001), but increased between 1 and 3 years postoperatively (p<.01). Change in depressive symptoms was significantly related to change in body mass index (r=.42; p<0001).
Conclusion
Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year.
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Citation
Obesity (Silver Spring, Md.); 22:8 p. 1799-1806
DOI
10.1002/oby.20738