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    Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker’s Vacuum Packing Technique

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    Author
    Cheatham, Michael L.; Demetriades, Demetrios; Fabian, Timothy C.; Kaplan, Mark J.; Miles, William S.; Schreiber, Martin A.; Holcomb, John B.; Bochicchio, Grant; Sarani, Babak; Rotondo, Michael F.
    Abstract
    Background The open abdomen has become a common procedure in the management of complex abdominal problems and has improved patient survival. The method of temporary abdominal closure (TAC) may play a role in patient outcome. Methods A prospective, observational, open-label study was performed to evaluate two TAC techniques in surgical and trauma patients requiring open abdomen management: Barker’s vacuum-packing technique (BVPT) and the ABTheraTM open abdomen negative pressure therapy system (NPWT). Study endpoints were days to and rate of 30-day primary fascial closure (PFC) and 30-day all-cause mortality. Results Altogether, 280 patients were enrolled from 20 study sites. Among them, 168 patients underwent at least 48 hours of consistent TAC therapy (111 NPWT, 57 BVPT). The two study groups were well matched demographically. Median days to PFC were 9 days for NPWT versus 12 days for BVPT (p = 0.12). The 30-day PFC rate was 69 % for NPWT and 51 % for BVPT (p = 0.03). The 30-day all-cause mortality was 14 % for NPWT and 30 % for BVPT (p = 0.01). Multivariate logistic regression analysis identified that patients treated with NPWT were significantly more likely to survive than the BVPT patients [odds ratio 3.17 (95 % confidence interval 1.22–8.26); p = 0.02] after controlling for age, severity of illness, and cumulative fluid administration. Conclusions Active NPWT is associated with significantly higher 30-day PFC rates and lower 30-day all-cause mortality among patients who require an open abdomen for at least 48 h during treatment for critical illness.
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    http://hdl.handle.net/10342/5860
    Date
    2013-05
    Citation:
    APA:
    Cheatham, Michael L., & Demetriades, Demetrios, & Fabian, Timothy C., & Kaplan, Mark J., & Miles, William S., & Schreiber, Martin A., & Holcomb, John B., & Bochicchio, Grant, & Sarani, Babak, & Rotondo, Michael F.. (May 2013). Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker’s Vacuum Packing Technique. World Journal of Surgery, (37:9), p.2018-2030. Retrieved from http://hdl.handle.net/10342/5860

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    MLA:
    Cheatham, Michael L., and Demetriades, Demetrios, and Fabian, Timothy C., and Kaplan, Mark J., and Miles, William S., and Schreiber, Martin A., and Holcomb, John B., and Bochicchio, Grant, and Sarani, Babak, and Rotondo, Michael F.. "Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker’s Vacuum Packing Technique". World Journal of Surgery. 37:9. (2018-2030.), May 2013. August 15, 2022. http://hdl.handle.net/10342/5860.
    Chicago:
    Cheatham, Michael L. and Demetriades, Demetrios and Fabian, Timothy C. and Kaplan, Mark J. and Miles, William S. and Schreiber, Martin A. and Holcomb, John B. and Bochicchio, Grant and Sarani, Babak and Rotondo, Michael F., "Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker’s Vacuum Packing Technique," World Journal of Surgery 37, no. 9 (May 2013), http://hdl.handle.net/10342/5860 (accessed August 15, 2022).
    AMA:
    Cheatham, Michael L., Demetriades, Demetrios, Fabian, Timothy C., Kaplan, Mark J., Miles, William S., Schreiber, Martin A., Holcomb, John B., Bochicchio, Grant, Sarani, Babak, Rotondo, Michael F.. Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker’s Vacuum Packing Technique. World Journal of Surgery. May 2013; 37(9) 2018-2030. http://hdl.handle.net/10342/5860. Accessed August 15, 2022.
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