The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume
Vohra, Nasreen A.; Kachare, Swapnil D.; Vos, Paul; Schroeder, Bruce F.; Schuth, Olga; Suttle, Dylan; Fitzgerald, Timothy L.; Wong, Jan H.; Verbanac, Kathryn M.
Purpose: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods. Materials and Methods: Fibroglandular volume, breast volume, and their ratio, the VBD, were calculated from mammograms before and after WLS by using Volpara™ automated software. Results: For the 80 women included, average body mass index decreased from 46.0 ± 7.22 to 33.7 ± 7.06 kg/m2. Mammograms were performed on average 11.6 ± 9.4 months before and 10.1 ± 7 months after WLS. There was a significant reduction in average breast volume (39.4 % decrease) and average fibroglandular volume (15.5 % decrease), and thus, the average VBD increased from 5.15 to 7.87 % (p < 1 × 10−9) after WLS. When stratified by menopausal status and diabetic status, VBD increased significantly in all groups but only perimenopausal and postmenopausal women and non-diabetics experienced a significant reduction in fibroglandular volume. Conclusions: Breast volume and fibroglandular volume decreased, and VBD increased following WLS, with the most significant change observed in postmenopausal women and non-diabetics. Further studies are warranted to determine how physical and biological alterations in breast density components after WLS may impact breast cancer risk.
Vohra, Nasreen A., & Kachare, Swapnil D., & Vos, Paul, & Schroeder, Bruce F., & Schuth, Olga, & Suttle, Dylan, & Fitzgerald, Timothy L., & Wong, Jan H., & Verbanac, Kathryn M.. (October 2016). The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume. Obesity Surgery, (1-11. Retrieved from http://hdl.handle.net/10342/5976
Vohra, Nasreen A., and Kachare, Swapnil D., and Vos, Paul, and Schroeder, Bruce F., and Schuth, Olga, and Suttle, Dylan, and Fitzgerald, Timothy L., and Wong, Jan H., and Verbanac, Kathryn M.. "The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume". Obesity Surgery. . (1-11.), October 2016. July 31, 2021. http://hdl.handle.net/10342/5976.
Vohra, Nasreen A. and Kachare, Swapnil D. and Vos, Paul and Schroeder, Bruce F. and Schuth, Olga and Suttle, Dylan and Fitzgerald, Timothy L. and Wong, Jan H. and Verbanac, Kathryn M., "The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume," Obesity Surgery , no. (October 2016), http://hdl.handle.net/10342/5976 (accessed July 31, 2021).
Vohra, Nasreen A., Kachare, Swapnil D., Vos, Paul, Schroeder, Bruce F., Schuth, Olga, Suttle, Dylan, Fitzgerald, Timothy L., Wong, Jan H., Verbanac, Kathryn M.. The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume. Obesity Surgery. October 2016; () 1-11. http://hdl.handle.net/10342/5976. Accessed July 31, 2021.
Showing items related by title, author, creator and subject.
Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer:5-year results for local control and overall survival from the TARGIT-A randomised trial Vaidya, Jayant S; Wenz, Frederik; Bulsara, Max; Tobias, Jeffrey S; Joseph, David J; Keshtgar, Mohammed; Flyger, Henrik L; Massarut, Samuele; Alvarado, Michael; Saunders, Christobel; Eiermann, Wolfgang; Metaxas, Marinos; Sperk, Elena; Sütterlin, Marc; Brown, Douglas; Esserman, Laura; Roncadin, Mario; Thompson, Alastair; Dewar, John A; Holtveg, Helle M R; Pigorsch, Steffi; Falzon, Mary; Harris, Eleanor; Matthews, April; Brew-Graves, Chris; Potyka, Ingrid; Corica, Tammy; Williams, Norman R; Baum, Michael (2014-02-14)The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer. We report 5-year results for ...
Differences in reproductive risk factors for breast cancer in middle-aged women in Marin County, California and a sociodemographically similar area of Northern California Lea, C. Suzanne; Gordon, Nancy P.; Prebil, Lee Ann; Ereman, Rochelle; Uratsu, Connie S.; Powell, Mark (East Carolina University, 2009-03-25)Background: The Northern California county of Marin (MC) has historically had high breast cancer incidence rates. Because of MC's high socioeconomic status (SES) and racial homogeneity (non-Hispanic White), it has been ...
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells Crosson, Whitney K. (East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ...