The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume
Vohra, Nasreen A.; Kachare, Swapnil D.; Vos, Paul; Schroeder, Bruce F.; Schuth, Olga; Suttle, Dylan; Fitzgerald, Timothy L.; Wong, Jan H.; Verbanac, Kathryn M.
Purpose: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods. Materials and Methods: Fibroglandular volume, breast volume, and their ratio, the VBD, were calculated from mammograms before and after WLS by using Volpara™ automated software. Results: For the 80 women included, average body mass index decreased from 46.0 ± 7.22 to 33.7 ± 7.06 kg/m2. Mammograms were performed on average 11.6 ± 9.4 months before and 10.1 ± 7 months after WLS. There was a significant reduction in average breast volume (39.4 % decrease) and average fibroglandular volume (15.5 % decrease), and thus, the average VBD increased from 5.15 to 7.87 % (p < 1 × 10−9) after WLS. When stratified by menopausal status and diabetic status, VBD increased significantly in all groups but only perimenopausal and postmenopausal women and non-diabetics experienced a significant reduction in fibroglandular volume. Conclusions: Breast volume and fibroglandular volume decreased, and VBD increased following WLS, with the most significant change observed in postmenopausal women and non-diabetics. Further studies are warranted to determine how physical and biological alterations in breast density components after WLS may impact breast cancer risk.
Vohra, Nasreen A., & Kachare, Swapnil D., & Vos, Paul, & Schroeder, Bruce F., & Schuth, Olga, & Suttle, Dylan, & Fitzgerald, Timothy L., & Wong, Jan H., & Verbanac, Kathryn M.. (October 2016). The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume. Obesity Surgery, (1-11. Retrieved from http://hdl.handle.net/10342/5976
Vohra, Nasreen A., and Kachare, Swapnil D., and Vos, Paul, and Schroeder, Bruce F., and Schuth, Olga, and Suttle, Dylan, and Fitzgerald, Timothy L., and Wong, Jan H., and Verbanac, Kathryn M.. "The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume". Obesity Surgery. . (1-11.), October 2016. February 19, 2020. http://hdl.handle.net/10342/5976.
Vohra, Nasreen A. and Kachare, Swapnil D. and Vos, Paul and Schroeder, Bruce F. and Schuth, Olga and Suttle, Dylan and Fitzgerald, Timothy L. and Wong, Jan H. and Verbanac, Kathryn M., "The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume," Obesity Surgery , no. (October 2016), http://hdl.handle.net/10342/5976 (accessed February 19, 2020).
Vohra, Nasreen A., Kachare, Swapnil D., Vos, Paul, Schroeder, Bruce F., Schuth, Olga, Suttle, Dylan, Fitzgerald, Timothy L., Wong, Jan H., Verbanac, Kathryn M.. The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume. Obesity Surgery. October 2016; () 1-11. http://hdl.handle.net/10342/5976. Accessed February 19, 2020.
Showing items related by title, author, creator and subject.
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line Long, Jacquelyn M.; Bell, Charles W.; Fagg, W. Samuel IV; Kushman, Mary E.; Becker, Kevin G.; McCubrey, James A.; Farwell, Mary A. (East Carolina University, 2008-10)Bcl-2 is an anti-apoptotic protein that is frequently overex-pressed in cancer cells but its role in carcinogenesis is not clear. We are interested in how Bcl-2 expression affects non-cancerous breast cells and its role ...
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer Di, Li-Jun; Byun, Jung S.; Wong, Madeline M.; Wakano, Clay; Taylor, Tara; Bilke, Sven; Baek, Songjoon; Hunter, Kent; Yang, Howard; Lee, Maxwell; Zvosec, Celia; Khramtsova, Galina; Cheng, Fan; Perou, Charles M.; Miller, C. Ryan; Raab, Rachel; Olopade, Olufunmilayo I.; Gardner, Kevin (http://www.ncbi.nlm.nih.gov/pubmed/23385593, 2013-1)
Winfrey, William Brandon (East Carolina University, 2013)Human cancer is the second leading cause of death in the United States and breast cancer is responsible for the second highest number of deaths in women with cancer worldwide. Today, cancer is becoming more and more ...