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Karyotype analysis and sex determination in Australian Brush-turkeys (Alectura lathami)
(2017-09-14)
Sexual differentiation across taxa may be due to genetic sex determination (GSD) and/or temperature sex determination (TSD). In many mammals, males are heterogametic (XY); whereas females are homogametic (XX). In most ...
Limited indications of tax stamp discordance and counterfeiting on cigarette packs purchased in tobacco retailers, 97 counties, USA, 2012
(2017-09-28)
Increasing the per-unit cost of tobacco products is one of the strongest interventions for tobacco control. In jurisdictions with higher taxes in the U.S., however, cigarette pack litter studies show a substantial proportion ...
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
(2017-08-24)
A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ...
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
(2017-02-21)
Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy
in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the ...
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
(2017-12-21)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry.
We recently demonstrated ...
Potential Mechanisms and Functions of Intermittent Neural Synchronization
(2017-05-30)
Neural synchronization is believed to play an important role in different brain functions. Synchrony in cortical and subcortical circuits is frequently variable in time and not perfect. Few long intervals of desynchronized ...
Dimeric and tetrameric forms of muscle fructose-1,6- bisphosphatase play different roles in the cell
(2017-12-15)
Muscle fructose 1,6-bisphosphatase (FBP2), besides being a regulatory enzyme of glyconeogenesis also protects mitochondria against calcium stress and plays a key role in regulation of the cell cycle, promoting cardiomyocytes ...
Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study
(2017-04)
Background: Electromagnetic navigation bronchoscopy (ENB) is an image-guided, minimally invasive approach that uses a flexible catheter to access pulmonary lesions.
Methods: NAVIGATE is a prospective, multicenter study ...
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
(2017-11)
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all as- sociated with mitochondrial dysfunction in skeletal muscle. ...
Feasibility and Efficacy of Prolonged Exposure for PTSD among Individuals with a Psychotic Spectrum Disorder
(2017-06-28)
Objective: Few empirical studies have examined the feasibility of trauma-focused treatment among individuals with schizophrenia. This lack of research is important given the substantial overlap of trauma exposure and ...