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The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy

Simioni, Carolina; Martelli, Alberto M.; Cani, Alice; Cetin-Atalay, Rengul; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2013-08-24)

Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ...