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    THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL

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    Author
    Elliott, Zachary
    Abstract
    Chemotherapy drugs have neurotoxicity associated with treatment, which can become a dose-limiting problem when clinical presentation is severe. However, there is no effective therapy to circumvent the neurotoxicity of anti-cancer drug treatment. In this study, we utilized a newly designed mouse model of cisplatin-induced peripheral neuropathy to determine both the severity of neurotoxicity induced by drug treatment and the effectiveness of the Rho kinase inhibitor Y-27632. Sensory nerve conduction studies revealed a significant increase in mean distal latency with cisplatin treatment, indicating a deterioration of sensory nerve function. Also, hind paw touch sensitivity decreased steadily with increasing cumulative dose of cisplatin. Von Frey analysis indicated a protective effect in mice treated with Y-27632. Histological and immunohistochemical analyses of the sural nerve using neuronal marker protein gene product s100 and CGRP demonstrated abnormal nerve fiber morphology in cisplatin-treated mice, but not in those treated with Y-27632. These studies suggest that Rho kinase inhibitor Y-27632 can ameliorate the damage caused by cisplatin in sensory related nerves but has no effect in nociceptor nerve endings.
    URI
    http://hdl.handle.net/10342/6877
    Subject
    Cisplatin, chemotherapy, CIPN
    Date
    2018-05-01
    Citation:
    APA:
    Elliott, Zachary. (May 2018). THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL (Honors Thesis, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/6877.)

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    MLA:
    Elliott, Zachary. THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL. Honors Thesis. East Carolina University, May 2018. The Scholarship. http://hdl.handle.net/10342/6877. September 26, 2023.
    Chicago:
    Elliott, Zachary, “THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL” (Honors Thesis., East Carolina University, May 2018).
    AMA:
    Elliott, Zachary. THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL [Honors Thesis]. Greenville, NC: East Carolina University; May 2018.
    Collections
    • Health Education and Promotion
    • Honors College
    Publisher
    East Carolina University

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