THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL
Author
Elliott, Zachary
Abstract
Chemotherapy drugs have neurotoxicity associated with treatment, which can become a dose-limiting problem when clinical presentation is severe. However, there is no effective therapy to circumvent the neurotoxicity of anti-cancer drug treatment. In this study, we utilized a newly designed mouse model of cisplatin-induced peripheral neuropathy to determine both the severity of neurotoxicity induced by drug treatment and the effectiveness of the Rho kinase inhibitor Y-27632. Sensory nerve conduction studies revealed a significant increase in mean distal latency with cisplatin treatment, indicating a deterioration of sensory nerve function. Also, hind paw touch sensitivity decreased steadily with increasing cumulative dose of cisplatin. Von Frey analysis indicated a protective effect in mice treated with Y-27632. Histological and immunohistochemical analyses of the sural nerve using neuronal marker protein gene product s100 and CGRP demonstrated abnormal nerve fiber morphology in cisplatin-treated mice, but not in those treated with Y-27632. These studies suggest that Rho kinase inhibitor Y-27632 can ameliorate the damage caused by cisplatin in sensory related nerves but has no effect in nociceptor nerve endings.
Subject
Date
2018-05-01
Citation:
APA:
Elliott, Zachary.
(May 2018).
THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL
(Honors Thesis, East Carolina University). Retrieved from the Scholarship.
(http://hdl.handle.net/10342/6877.)
MLA:
Elliott, Zachary.
THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL.
Honors Thesis. East Carolina University,
May 2018. The Scholarship.
http://hdl.handle.net/10342/6877.
September 26, 2023.
Chicago:
Elliott, Zachary,
“THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL”
(Honors Thesis., East Carolina University,
May 2018).
AMA:
Elliott, Zachary.
THE THERAPEUTIC EFFECT OF RHO KINASE INHIBITOR Y-27632 ON PROTECTION FROM CHEMOTHERAPY INDUCED PERIPHEAL NEUROPATHY IN MOUSE MODEL
[Honors Thesis]. Greenville, NC: East Carolina University;
May 2018.
Collections
Publisher
East Carolina University