Browsing Health Sciences Campus by Author "Darden, Timothy M."
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Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
Anderson, Ethan; Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Wesley T.; Darden, Timothy M.; Thayne, Kathleen A.; Katunga, Lalage Adalaide; Kindell, Linda C.; Ferguson, T. Bruce; Anderson, Curtis A.; Chitwood, W. Randolph; Koutlas, Theodore C.; Williams, J. Mark; Rodriguez, Evelio; Kypson, Alan P. (2014-02)BACKGROUND: Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and ... -
Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage Adalaide; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A. I.; Anderson, Ethan (2015-04)Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ... -
Use of monoamine oxidase and redox enzymes in atrial tissue as novel predictors of postoperative atrial fibrillation
Darden, Timothy M. (East Carolina University, 2014)Postoperative atrial fibrillation (POAF) occurs in approximately 30% of cardiac surgery patients. The complication occurs despite advances in surgical procedures. It is associated with increased mortality, morbidity, and ...