Browsing Health Sciences Campus by Author "Pearson, James P."
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Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue
Branny, Pavel; Pearson, James P.; Pesci, Everett C.; Kohler, Thilo; Iglewski, Barbara H.; Van Delden, Christian (East Carolina University, 2001-03)The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion ... -
Novel autoinducer molecules and uses therefor
Greenberg, Everett; Iglewski, Barbara; Kende, Andrew; Milbank, Jared B. J.; Pearson, James P.; Pesci, Everett (2002-03-07)Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic ... -
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
Pesci, Everett C.; Milbank, Jared B. J.; Pearson, James P.; McKnight, Susan L.; Kende, Andrew S.; Greenberg, E. Peter; Iglewski, Barbara H. (East Carolina University, 1999-09-28)Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ...