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Now showing items 11-15 of 15
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)
Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ...
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)
Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ...
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
(East Carolina University, 2016-05-03)
Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ...
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)
Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ...