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Now showing items 1211-1220 of 2687
The Endocannabinoid System Regulates Synaptogenesis in a Cortical Spheroid Model of Fetal Neurodevelopment
(East Carolina University, 2021-07-20)
The endocannabinoid system plays a complex role in synaptogenesis and the subsequent development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 controls synaptic strength at both ...
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)
Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ...
Borrelia burgdorferi ErpB and ErpQ inhibit C1 complex of the classical pathway of complement through a novel mechanism
(East Carolina University, 2021-05-03)
The complement system is an organized proteolytic cascade of dozens of proteins that functions in the recognition, opsonization, and lysis of pathogenic and altered-host cells. Bloodborne pathogens like the etiologic agent ...
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
(East Carolina University, 2021-05-04)
Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ...
PUF-8 and MPK-1: Genetic and Chemical Control of Spermatocyte Dedifferentiation in Caenorhabditis elegans
(East Carolina University, 2021-05-03)
Stem cells face a number of major fate decision during their development: the decision to self-renew or differentiate, and then whether to remain differentiated or dedifferentiate, as occurs in some oncogenesis. A regulatory ...
Diet can help manage polycystic ovary syndrome
(2021-06-09)
This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is on how diet can help patients manage their polycystic ovary syndrome.
The Circadian Rhythm and its Role in the Dynamic Dopamine Neuron Phenotype
(East Carolina University, 2021-05-04)
The circadian rhythm is strongly implicated in many neuropsychiatric and neurodegenerative disorders, all of which are associated with altered dopamine (DA) neurotransmission in the substantia nigra and ventral tegmental ...
Factors Correlated with Communication Confidence in Persons with Aphasia: A Synthetic Cohort Analysis
(East Carolina University, 2021-04-15)
Aphasia is an acquired language disorder that affects a person's communication abilities. Consequently, aphasia can have a profound impact on how persons with aphasia (PWA) experience their personal life. Recently, approaches ...
Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)
Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ...
AN EPIDEMIOLOGIC ANALYSIS OF SARCOIDOSIS IN NC
(East Carolina University, 2021-12-15)
Sarcoidosis is a rare, complex inflammatory chronic condition that commonly affects the lymphatic system and the lungs. The clinical course of sarcoidosis can vary from acute to progressively chronic conditions including ...