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Understanding the Molecular Mechanisms that Contribute to Parkinson’s Disease: Defining the Role of Ca2+ in TG2: α-synuclein Macromolecular Complex Assembly
(East Carolina University, 2018-12-10)
Transglutaminase 2 (TG2) is an allosteric enzyme ubiquitously expressed in human tissue. This versatile enzyme has both Ca2+ -dependent, transamidase and GTPase activities. TG2's Ca2+ -dependent transamidase activity is ...
Improving Depression Screening in the Adult Rural Primary Care Setting
(2018-11-27)
An estimated 16 million adults are diagnosed each year with depression with primary care providers most commonly making the diagnosis. Depression screening guidelines from the United States Preventive Services Task Force ...
Implementation of a Sensory Modulation Room on an Acute Care Psychiatric Unit
(2018-11-26)
The application of sensory modulation approaches in psychiatric mental health hospital settings
is growing in recognition and implementation internationally. This treatment modality offers
alternatives to use of more ...
Improving HPV Vaccination in Adolescents: A Quality Improvement Initiative
(2018-11-28)
Background: Human Papillomavirus (HPV) related cancers are preventable if vaccinated. Opportunities to administer the HPV vaccination to adolescents were being missed with a rural, primary care clinic due to lack of ...
Enhancing Provider Education to Increase HPV Vaccination Rates in Adolescents
(2018-11-29)
Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and in the United States. Despite ACIP recommendations and Healthy People 2020 goals, HPV vaccination completion rates in North ...
Improving Documentation of Symptom Management in General In-Patient Hospice
(2018-11-08)
The purpose of this quality improvement (QI) project was to evaluate nursing compliance of using an evidence-based flowsheet for General In-Patient (GIP) symptom management with a secondary purpose of improving nursing ...
Blood Pressure and Heart Rate Screenings in Physical Therapy: An Interprofessional DNP Project
(2018-11-26)
Physical therapists are increasing their autonomous practice, which includes direct patient referral without a provider first assessing the patient. The Guide to Physical Therapist Practice recommends that every patient ...
A COMPARISON OF THE EFFICACY OF KEYBOARDING WITHOUT TEARS PROGRAM AND MIXED METHOD INSTRUCTION
(East Carolina University, 2018-11-27)
The purpose of this study was to investigate the two-year impact of using the Keyboarding Without Tears[trademark] instruction program compared to a mixed method instruction approach on students' net typing words per minute ...
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
(East Carolina University, 2018-07-17)
Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ...
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
(East Carolina University, 2018-07-25)
EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ...