Now showing items 1-5 of 5
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ...
GSK-3 as potential target for therapeutic intervention in cancer
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of GSK-3 ...
Analysis of the mutation in cutaneous melanoma patients with occupational sun exposure
Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ...
Multifaceted roles of GSK-3 and Wnt/Î²-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated ...
Emerging targeted therapies for melanoma treatment (Review)
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development ...