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Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
(East Carolina University, 2008-07)
Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ...
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
(East Carolina University, 2008-01-11)
delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ...