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Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)
Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ...
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)
Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ...
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)
Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ...