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THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
(East Carolina University, 2019-07-26)
Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ...
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)
With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ...
THE PRO-INFLAMMATORY ROLE OF G-PROTEIN COUPLED RECEPTOR 4 IN AN ACIDIC MICROENVIRONMENT
(East Carolina University, 2018-07-20)
The endothelium of the microvascular system serves an ideal mediator between circulating blood and tissues in order to regulate systemic homeostasis. During vascular disease, the normal function and phenotype of endothelial ...
TIMECOURSE OF SYNAPSE DEVELOPMENT IN HUMAN IPSC-DERIVED NEURONS
(East Carolina University, 2019-06-12)
Understanding the underlying mechanisms in brain formation give an insight to what affects the formation of the brain when affected with autism, specifically, the excitatory and inhibitory synapses. The mechanism of how ...
Multiple target hybridizing nucleic acids, their preparation, compositions, formulation, kits and applications
(1999-03-25)
Antisense oligonucleotides which bind to two or more RNA targets are disclosed.
FUNCTIONS OF CLAUDIN-7 IN THE SELF-RENEWAL OF INTESTINAL EPITHELIUM
(East Carolina University, 8/5/2020)
Tight junctions (TJ) are located at the most apical region of the junctional complex and contain many integral membrane proteins. Claudin 7 (Cldn7) is a TJ membrane protein located at the apical TJ and basolateral side of ...
Do Pesticides cause Obesity and Diabetes?
(2019-08-05)
We have an epidemic of obesity that presents with serious health and economic consequences.
Obesity is the most common disease in the U.S. that has developed rapidly in only a matter of decades.
Glyphosate (RoundupTM) ...
The therapeutic effect of Rho kinase inhibitor Y-27632 on protection from chemotherapy-induced peripheral neuropathy
(2018-04-17)
Cisplatin often causes loss of touch sensitivity in the hands and feet of cancer patients as well as tingling, numbness, and a shooting or burning pain; these clinical symptoms are referred to as chemotherapy-induced ...
The therapeutic effect of Rho kinase inhibitor Y-27632 on protection from chemotherapy-induced peripheral neuropathy
(2018-03-26)
Cisplatin often causes loss of touch sensitivity in the hands and feet of cancer patients as well as tingling, numbness, and a shooting or burning pain; these clinical symptoms are referred to as chemotherapy-induced ...