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Now showing items 51-60 of 66
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)
Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...
Inhibition of Nischarin Expression Attenuates Rilmenidine-Evoked Hypotension and Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Production in the Rostral Ventrolateral Medulla of Rats
(East Carolina University, 2008-01)
Imidazoline (I1)-evoked hypotension is linked to enhanced phosphorylated extracellular signalregulated kinase (pERK)1/2 production in the rostral ventrolateral medulla (RVLM). Recent cell
culture findings suggest that ...
A Minimally-Invasive Procedure for Sexing Young Zebra Finches
(East Carolina University, 2007-08-15)
Zebra finches have been widely used to study neurobiology underlying vocal development. Because only male zebra finches learn song, efficient developmental use of these animals requires early determination of sex at ages ...
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)
Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ...
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats
(East Carolina University, 2009-01-16)
Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses
elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in
telemetered female rats.
Main ...
Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats
(East Carolina University, 2009-02)
Background- Our previous pharmacological and cellular studies showed that peripheral (cardiac and vascular) NOS-derived NO is implicated in the estrogen-dependent hypotensive action of ethanol in female rats. The objective ...
CB1 Cannabinoid Receptor Activation Dose-Dependently Modulates Neuronal Activity within Caudal but not Rostral Song Control Regions of Adult Zebra Finch Telencephalon
(East Carolina University, 2008-08)
CB1 cannabinoid receptors are distinctly expressed at high density within several regions of zebra finch telencephalon including those known to be involved in song learning (lMAN and Area X) and production (HVC and RA). ...
Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats
(East Carolina University, 2005-03-30)
Background: In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase ...
Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition
(East Carolina University, 2007-01)
Cyclooxygenase 2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins, and COX-2 overexpression plays an important role in carcinogenesis. Exposure to UVB strongly increased COX-2 protein expression ...
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal
(East Carolina University, 2006-08-22)
Every physiological function in the human body exhibits some form of circadian rhythmicity. Under pathological conditions, however, circadian rhythmicity may be dusrupted. Patients infected with HIV or addicted to drugs ...