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CB1 Cannabinoid Receptor Activation Dose-Dependently Modulates Neuronal Activity within Caudal but not Rostral Song Control Regions of Adult Zebra Finch Telencephalon
(East Carolina University, 2008-08)
CB1 cannabinoid receptors are distinctly expressed at high density within several regions of zebra finch telencephalon including those known to be involved in song learning (lMAN and Area X) and production (HVC and RA). ...
Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats
(East Carolina University, 2005-03-30)
Background: In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase ...
Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition
(East Carolina University, 2007-01)
Cyclooxygenase 2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins, and COX-2 overexpression plays an important role in carcinogenesis. Exposure to UVB strongly increased COX-2 protein expression ...
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal
(East Carolina University, 2006-08-22)
Every physiological function in the human body exhibits some form of circadian rhythmicity. Under pathological conditions, however, circadian rhythmicity may be dusrupted. Patients infected with HIV or addicted to drugs ...
Bone marrow stromal cells attenuate sepsis via prostaglandin E2— dependent reprogramming of host macrophages to increase their interleukin-10 production
(East Carolina University, 2009-01)
Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis ...
INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
(East Carolina University, 2022-06-27)
Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional ...
Investigating Non-Tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein Nanoarchitecture
(East Carolina University, 2022-12-12)
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Discovering mechanisms during spermatogonial differentiation that prepare male germ cells for meiosis
(East Carolina University, 2022-12-05)
Spermatogenesis, the male germ cell maturation process, allows men to become and remain fertile for decades. Male fertility relies on fate decisions of different types of spermatogonia – spermatogonial stem cells maintain ...