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CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)
Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ...
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)
In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ...
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
(East Carolina University, 2014)
The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and ...
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)
Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ...