Browsing Open Access by Author "Baraf, Herbert S. B."
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Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: Two randomized controlled trials
Sundy, John S.; Baraf, Herbert S. B.; Yood, Robert A.; Edwards, N. Lawrence; Gutierrez-Urena, Sergio R.; Treadwell, Edward L.; Vazquez-Mellado, Janitzia; White, William B.; Lipsky, Peter E.; Horowitz, Zeb; Huang, William; Maroli, Allan N.; Waltrip II, Royce W.; Hamburger, Steven A.; Becker, Michael A. (2011-08-17)Context Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition. Pegloticase, monomethoxyp ... -
Tophus burden reduction with pegloticase: Results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy
Baraf, Herbert S. B.; Becker, Michael A; Gutierrez-Urena, Sergio R; Treadwell, Edward L; Vazquez-Mellado, Janitzia; Rehrig, Claudia D; Ottery, Faith D; Sundy, John S; Yood, Robert A (2013-09-26)Introduction Two replicate randomized, placebo-controlled six-month trials (RCTs) and an open-label treatment extension (OLE) comprised the pegloticase development program in patients with gout refractory to conventional ...