Browsing Open Access by Author "Cappellini, Alessandra"
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Therapeutic targeting of CK2 in acute and chronic leukemias
Buontempo, Francesca; McCubrey, JA; Orsini, E; Ruzzene, M; Cappellini, Alessandra; Lonetti, A; Evangelisti, Camilla; Chiarini, Francesca; Evangelisti, C; Barata, JT; Martelli, AM (2018-01)Phosphorylation can regulate almost every property of a protein and is involved in all fundamental cellular processes. Thus, proper regulation of phosphorylation events is critical to the homeostatic functions of cell ... -
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
Martelli, Alberto M.; Chiarini, Francesca; Evangelisti, Camilla; Cappellini, Alessandra; Buontempo, Francesca; Bressanin, Daniela; Fini, Milena; McCubrey, James A. (2012-05-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ...