Browsing Open Access by Author "Garcia, Brandon L."
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Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
Pickering, Amy C.; Vitry, Pauline; Prystopiuk, Valeriia; Garcia, Brandon L.; Höök, Magnus; Schoenebeck, Jeffrey; Geoghegan, Joan A.; Dufrêne, Yves F.; Fitzgerald, J. Ross (2019-06)Fibrinogen is an essential part of the blood coagulation cascade and a major component of the extracellular matrix in mammals. The interface between fibrinogen and bacterial pathogens is an important determinant of the ... -
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
Xie, Jialei; Zhi, Hui; Garrigues, Ryan J.; Keightley, Andrew; Garcia, Brandon L.; Skare, Jon T. (2019-03-21)The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...