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Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish
(2014-12-19)
The zebrafish has significant advantages for studying the morphological development of the brain. However, little is known about the functional development of the zebrafish brain. We used patch clamp electrophysiology in ...
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
(2019-11-08)
Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ...
Chromosome evolution in Cophomantini (Amphibia, Anura, Hylinae)
(2018-02-14)
The hylid tribe Cophomantini is a diverse clade of Neotropical treefrogs composed of the genera Aplastodiscus, Boana, Bokermannohyla, Hyloscirtus, and Myersiohyla. The phylogenetic relationships of Cophomantini have been ...
Clinical Outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): A Randomized Clinical Trial
(2017-08-23)
BACKGROUND:
The Systolic Blood Pressure Intervention Trial (SPRINT) showed that targeting a systolic blood pressure (SBP) of ≤ 120 mm Hg (intensive treatment) reduced cardiovascular disease (CVD) events compared to SBP ...
Co-occurrence of ecologically similar species of Hawaiian spiders reveals critical early phase of adaptive radiation
(2018-06-19)
Background:
The processes through which populations originate and diversify ecologically in the initial stages of adaptive radiation are little understood because we lack information on critical steps of early divergence. ...
Before-school running/walking club: Effects on student on-task behavior
(2016-02-01)
Before-school programs provide a good opportunity for children to engage in physical activity (PA) as well as im- prove their readiness to learn. The purpose of this study was to examine the effect of a before-school ...
Crop rotational diversity increases disease suppressive capacity of soil microbiomes
(2018-05-15)
Microbiomes can aid in the protection of hosts from infection and disease, but the mechanisms underpinning these functions in complex environmental systems remain unresolved. Soils contain microbiomes that influence plant ...
Cutaneous melanoma: From pathogenesis to therapy (Review)
(2018-02-27)
In less than 10 years, melanoma treatment has been
revolutionized with the approval of tyrosine kinase inhibitors
and immune checkpoint inhibitors, which have been shown
to have a significant impact on the prognosis of ...
COMT Inhibition Alters Cue-Evoked Oscillatory Dynamics during Alcohol Drinking in the Rat
(2018-10-12)
Alterations in the corticostriatal system have been implicated in numerous substance use disorders, including
alcohol use disorder (AUD). Adaptations in this neural system are associated with enhanced drug-seeking
behaviors ...
Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex.
(2018-11-09)
Periplasmic flagella are essential for the distinct morphology and motility of spirochetes. A
flagella-specific type III secretion system (fT3SS) composed of a membrane-bound export
apparatus and a cytosolic ATPase complex ...