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The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
(2018-01-02)
Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ...
Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-series
(2018-12-16)
Background
With the advent of immune-checkpoint inhibitors and targeted treatments (TT), there have been unprecedented response rates and survival in advanced melanoma, but the optimal sequencing of these two treatments ...
Venous varices of the heart: a case report of spontaneous coronary sinus thrombosis with persistent left superior vena cava
(2018-08-16)
Absence of coronary sinus (CS) ostium and presence of a persistent superior left vena cava (PLSVC) are rare congenital anomalies.1 We report a case of spontaneous CS thrombosis with PLSVC associated with new-onset atrial ...
TEAM-UP for quality: a cluster randomized controlled trial protocol focused on preventing pressure ulcers through repositioning frequency and precipitating factors
(2018-02-20)
Background: Pressure ulcers/injuries (PrUs), a critical concern for nursing homes (NH), are responsible for chronic wounds, amputations, septic infections, and premature deaths. PrUs occur most commonly in older adults and ...
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development
(2018-10-10)
The transition of rod precursor cells to post-mitotic rod photoreceptors can be promoted by extrinsic factors such as insulin-like growth factor 1 (IGF- 1), which regulates phosphatidylinositide concentration, and consequently ...
Temperature Influences Herbivory and Algal Biomass in the Galápagos Islands
(2018-08-17)
Temperature can influence trophic interactions via predictable effects on the metabolism of ecothermic consumers. Under some conditions, warming should increase top–down control, and trophic transfer rates, leading to ...
The Continuing Fellowship Conundrum
(2018-02-11)
The debate for a fair, equitable, and reasonable pathology fellowship application and selection process has been an ongoing issue with ebb and flow over approximately the past 10 years. The authors of this commentary have ...
Temporal dynamics of genetic clines of invasive European green crab (Carcinus maenas) in eastern North America
(2018-06-08)
Two genetically distinct lineages of European green crabs (Carcinus maenas) were in- dependently introduced to eastern North America, the first in the early 19th century and the second in the late 20th century. These ...
The Populus holobiont: dissecting the effects of plant niches and genotype on the microbiome
(2018-02-12)
Background: Microorganisms serve important functions within numerous eukaryotic host organisms. An understanding of the variation in the plant niche-level microbiome, from rhizosphere soils to plant canopies, is imperative ...
The influence of impact-based severe weather warnings on risk perceptions and intended protective actions
(2018-04-03)
This paper presents the results of an online survey of the New Zealand public (n = 1364), conducted in 2015, that tested the influence of impact-based severe weather warnings on risk perceptions and intended protective ...