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The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response
(2019-05-06)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of pediatric and ~25% of adult ALL cases. Although the curative rates have significantly improved over the past 10 years, ...
Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks
(2019-02-05)
Background:
Neoadjuvant chemoradiation therapy (nCRT) has become the standard of care for esophageal cancer patients prior to esophagectomy. However, the optimal timing for surgery after completion of nCRT remains ...
Towards measuring resilience of flood-prone communities: a conceptual framework
(2019-06-17)
Community resilience has become an important
policy and research concept for understanding and addressing the challenges associated with the interplay of climate
change, urbanization, population growth, land use, ...
The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation
(2019-03-05)
Objective:
Valid, reliable, and clinically relevant outcome measures are necessary in clinical studies of snake envenomation. The aim of this study was to evaluate the psychometric (validity and reliability) and clinimetric ...
The effects of temperature on Bosmina longirostris susceptibility to microcystin-LR acute toxicity
(2019-07-09)
Harmful algal blooms are an ongoing threat to many aquatic systems throughout the world. In the Chowan River, North Carolina, the frequency of toxin producing Microcystis aeruginosa blooms has increased since 1975 along ...
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
(2019-01-10)
Characterization of small oligomers formed at an early stage of amyloid formation is critical to
understanding molecular mechanism of pathogenic aggregation process. Here we identifed and
characterized cytotoxic oligomeric ...
TOXIFY: a deep learning approach to classify animal venom proteins
(2019-06-28)
In the era of Next-Generation Sequencing and shotgun proteomics, the sequences
of animal toxigenic proteins are being generated at rates exceeding the pace of
traditional means for empirical toxicity verification. To ...
International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing
(2019-01-07)
In this Position Statement, the International Society of Sports Nutrition (ISSN) provides an objective and critical review of the literature pertinent to nutritional considerations for training and racing in single-stage ...
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
(2019-03-31)
In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ...
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)
PURPOSE:
Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ...