Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer
Nguyen, Nam P.; Ceizyk, Misty; Vock, Jacqueline; Vos, Paul; Chi, Alexander; Vinh-Hung, Vincent
Purpose The study aims to assess the tolerance of elderly patients (70 years or older) with locally advanced rectal cancers to image-guided radiotherapy (IGRT). A retrospective review of 13 elderly patients with locally advanced rectal cancer who underwent preoperative chemoradiation using IGRT was performed. Grade 3–4 acute toxicities, survival, and long-term complications were compared to 17 younger patients (<70 years) with the same disease stage. Results Grade 3–4 hematologic toxicities occurred in 7.6% and 0% (p = 0.4) and gastrointestinal toxicities, and, in 15.2% and 5% (p = 0.5), of elderly and younger patients, respectively. Surgery was aborted in three patients, two in the elderly group and one in the younger group. One patient in the elderly group died after surgery from cardiac arrhythmia. After a median follow-up of 34 months, five patients had died, two in the elderly and three in the younger group. The 3-year survival was 90.9% and 87.5% (p = 0.7) for the elderly and younger group respectively. Two patients in the younger group developed ischemic colitis and fecal incontinence. There was no statistically significant difference in acute and late toxicities as well as survival between the two groups. Conclusions and Clinical Relevance Elderly patients with locally advanced rectal cancers may tolerate preoperative chemoradiation with IGRT as well as younger patients. Further prospective studies should be performed to investigate the potential of IGRT for possible cure in elderly patients with locally advanced rectal cancer.
Nguyen, Nam P., & Ceizyk, Misty, & Vock, Jacqueline, & Vos, Paul, & Chi, Alexander, & Vinh-Hung, Vincent. (August 2013). Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer. PLoS ONE, (8:8), p.1-6. Retrieved from http://hdl.handle.net/10342/7679
Nguyen, Nam P., and Ceizyk, Misty, and Vock, Jacqueline, and Vos, Paul, and Chi, Alexander, and Vinh-Hung, Vincent. "Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer". PLoS ONE. 8:8. (1-6.), August 2013. February 28, 2021. http://hdl.handle.net/10342/7679.
Nguyen, Nam P. and Ceizyk, Misty and Vock, Jacqueline and Vos, Paul and Chi, Alexander and Vinh-Hung, Vincent, "Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer," PLoS ONE 8, no. 8 (August 2013), http://hdl.handle.net/10342/7679 (accessed February 28, 2021).
Nguyen, Nam P., Ceizyk, Misty, Vock, Jacqueline, Vos, Paul, Chi, Alexander, Vinh-Hung, Vincent. Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer. PLoS ONE. August 2013; 8(8) 1-6. http://hdl.handle.net/10342/7679. Accessed February 28, 2021.