Search
Now showing items 11-20 of 34
The C-terminus of Troponin T Modulates Calcium Regulation of Actin-Myosin Interactions
(East Carolina University, 2019-05-02)
The highly conserved terminal fourteen C-terminal residues of troponin T play a novel role in the regulation of striated muscle contraction. Elimination of the terminal fourteen residues of the C-terminal region of troponin ...
Relationship of N-glycans to Neuronal Dysfunction
(East Carolina University, 2019-06-07)
N-glycosylation is important in regulating protein activity and serves several vital roles contributing to protein folding, protein assembly, stability, and interactions. Changes in branching of N-glycans are linked to ...
NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
(2017-01-14)
A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, ...
Novel diagnostic and analytical applications of benchtop time-domain NMR.
(East Carolina University, 2015)
High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ...
Retinoids Potentiate Clinically Relevant Cellular Responses through RARα/RXR Nuclear Receptor Synergism in Cutaneous T Cell Lymphoma
(East Carolina University, 2015-12-15)
The heterogeneity of cutaneous T cell lymphoma (CTCL) has stifled treatment options and hindered cure development. Despite the heterogeneous nature of CTCLs, a hallmark of all variants is malignant T cell infiltration of ...
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)
During cell stress many biochemical processes are shut down. For
example, global mRNA translation initiation is inhibited due to the
disruption of the cap-dependent mRNA recruitment mechanism. One
specific example of ...
Kinetic and Thermodynamic Contributions to an Intermolecular Mechanism of Subunit Communication: Coordination of Pyruvate Carboxylase Activity Among Spatially Distinct Active Sites
(East Carolina University, 2016-07-13)
Catalysis occurring in a multifunctional enzyme at spatially distinct active sites is controlled by an array of factors, including the structure of the enzyme, ligand binding, and productive interaction of substrates to ...