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Troponin-tropomyosin: an allosteric switch or a steric blocker?
(East Carolina University, 2002-08)
The interaction of myosin subfragment 1 (S1) with actin-tropomyosin-troponin (regulated actin) is highly nucleotide dependent. The binding of S1 or S1-ADP (but not S1-ATP nor N,N - -phenylenedimaleimide-modified S1-ATP) ...
Novel autoinducer molecules and uses therefor
(2002-03-07)
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic ...
Catabolite repression control (crc) gene and pseudomonas virulence
(2002-08-22)
A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and ...
Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
(2002-10-17)
A method of reducing organ toxicity in a subject being administered a cytotoxic agent comprising concurrently administering with the cytotoxic agent erythropoietin (EPO), the EPO being administered in an amount effective ...