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    MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?

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    Author
    Baglivo, Ilaria; Pirone, Luciano; Malgieri, Gaetano; Fattorusso, Roberto; Roop, Roy Martin II; Pedone, Emilia Maria; Pedone, Paolo Vincenzo
    Abstract
    The protein MucR from Brucella spp. is involved in the expression regulation of genes necessary for host interaction and infection. MucR is a member of the Ros/MucR family, which comprises prokaryotic zinc-finger proteins and includes Ros from Agrobacterium tumefaciens and the Ml proteins from Mesorhizobium loti. MucR from Brucella spp. can regulate the expression of virulence genes and repress its own gene expression. Despite the well-known role played by MucR in the repression of its own gene, no target sequence has yet been identified in the mucR promoter gene. In this study, we provide the first evidence that MucR from Brucella abortus binds more than one target site in the promoter region of its own gene, suggesting a molecular mechanism by which this protein represses its own expression. Furthermore, a circular dichroism analysis reveals that MucR is a heat-stable protein. Overall, the results of this study suggest that MucR might resemble a H-NS protein.
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    http://hdl.handle.net/10342/7701
    Date
    2018-03-31
    Citation:
    APA:
    Baglivo, Ilaria, & Pirone, Luciano, & Malgieri, Gaetano, & Fattorusso, Roberto, & Roop, Roy Martin II, & Pedone, Emilia Maria, & Pedone, Paolo Vincenzo. (March 2018). MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?. FEBS Open Bio, (8:4), p.711-718. Retrieved from http://hdl.handle.net/10342/7701

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    MLA:
    Baglivo, Ilaria, and Pirone, Luciano, and Malgieri, Gaetano, and Fattorusso, Roberto, and Roop, Roy Martin II, and Pedone, Emilia Maria, and Pedone, Paolo Vincenzo. "MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?". FEBS Open Bio. 8:4. (711-718.), March 2018. March 01, 2021. http://hdl.handle.net/10342/7701.
    Chicago:
    Baglivo, Ilaria and Pirone, Luciano and Malgieri, Gaetano and Fattorusso, Roberto and Roop, Roy Martin II and Pedone, Emilia Maria and Pedone, Paolo Vincenzo, "MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?," FEBS Open Bio 8, no. 4 (March 2018), http://hdl.handle.net/10342/7701 (accessed March 01, 2021).
    AMA:
    Baglivo, Ilaria, Pirone, Luciano, Malgieri, Gaetano, Fattorusso, Roberto, Roop, Roy Martin II, Pedone, Emilia Maria, Pedone, Paolo Vincenzo. MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?. FEBS Open Bio. March 2018; 8(4) 711-718. http://hdl.handle.net/10342/7701. Accessed March 01, 2021.
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