Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer
Nguyen, Nam Phong; Shen, Wei; Kratz, Sarah; Vock, Jacqueline; Vos, Paul; Vincent, Vinh-Hung; Altdorfer, Gabor; Ewell, Lars; Jang, Siyoung; Karlsson, Ulf; Godinez, Juan; Mills, Melissa; Sroka, Thomas; Dutta, Suresh; Chi, Alexander; The International Geriatric Radiotherapy Group
Background: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT). Materials and Methods: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted. Results: Acute grade 3–4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2–24 months), no patients developed any radiation related toxicities such as grade 3–4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases. Conclusion: Grade 3–4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3–4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies.
Nguyen, Nam Phong, & Shen, Wei, & Kratz, Sarah, & Vock, Jacqueline, & Vos, Paul, & Vincent, Vinh-Hung, & Altdorfer, Gabor, & Ewell, Lars, & Jang, Siyoung, & Karlsson, Ulf, & Godinez, Juan, & Mills, Melissa, & Sroka, Thomas, & Dutta, Suresh, & Chi, Alexander, & The International Geriatric Radiotherapy Group. (November 2013). Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer. Frontiers in Oncology, (3:289), p.1-4. Retrieved from http://hdl.handle.net/10342/7713
Nguyen, Nam Phong, and Shen, Wei, and Kratz, Sarah, and Vock, Jacqueline, and Vos, Paul, and Vincent, Vinh-Hung, and Altdorfer, Gabor, and Ewell, Lars, and Jang, Siyoung, and Karlsson, Ulf, and Godinez, Juan, and Mills, Melissa, and Sroka, Thomas, and Dutta, Suresh, and Chi, Alexander, and The International Geriatric Radiotherapy Group. "Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer". Frontiers in Oncology. 3:289. (1-4.), November 2013. September 26, 2020. http://hdl.handle.net/10342/7713.
Nguyen, Nam Phong and Shen, Wei and Kratz, Sarah and Vock, Jacqueline and Vos, Paul and Vincent, Vinh-Hung and Altdorfer, Gabor and Ewell, Lars and Jang, Siyoung and Karlsson, Ulf and Godinez, Juan and Mills, Melissa and Sroka, Thomas and Dutta, Suresh and Chi, Alexander and The International Geriatric Radiotherapy Group, "Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer," Frontiers in Oncology 3, no. 289 (November 2013), http://hdl.handle.net/10342/7713 (accessed September 26, 2020).
Nguyen, Nam Phong, Shen, Wei, Kratz, Sarah, Vock, Jacqueline, Vos, Paul, Vincent, Vinh-Hung, Altdorfer, Gabor, Ewell, Lars, Jang, Siyoung, Karlsson, Ulf, Godinez, Juan, Mills, Melissa, Sroka, Thomas, Dutta, Suresh, Chi, Alexander, The International Geriatric Radiotherapy Group. Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer. Frontiers in Oncology. November 2013; 3(289) 1-4. http://hdl.handle.net/10342/7713. Accessed September 26, 2020.